The purpose of this study was preparation and evaluation of sustained release matrix type ocular mini-tablets of timolol maleate, as a potential formulation for the treatment of Glaucoma. Following the initial studies on timolol maleate powder, it was formulated into ocular mini-tablets. The polymers investigated in this study included cellulose derivatives (HEC, CMC, EC) and Carbopol971P. Mann...

The purpose of this study was preparation and evaluation of sustained release matrix type ocular mini-tablets of timolol maleate, as a potential formulation for the treatment of Glaucoma. Following the initial studies on timolol maleate powder, it was formulated into ocular mini-tablets. The polymers investigated in this study included cellulose derivatives (HEC, CMC, EC) and Carbopol971P. Mann...

Hydrophilic matrices, especially HPMC based, are widely used to provide sustained delivery where drug release occurs mainly by diffusion. A 3(2) full factorial design was used to develop and evaluate HPMC matrix tablet for sustained delivery of diclofenac. The influences of polymer concentration/viscosity, diluent type/ratio, drug load/solubility, compression force and pH change on drug release...

The current treatment approaches for allergic rhinitis are practiced over decades, but the patient quality of life has not yet changed so much. reasons research gaps in pathophysiology disease, proper management disease. Fexofenadine HCl is a second-generation antihistamine drug which half-life about 14.4 h. It useful common symptoms like sneezing, itchy throat, and red eyes individuals sufferi...

in this study, attempts were made to evaluate the effect of various acrylic acid based carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol hcl, from matrix-type tablets invitro. for this purpose, tablets containing 160 mg of propranolol hcl along with various amounts of carbopols 934 (c934), 971 (c971), 974 (c974) and pemulen (pem) were prepared using the wet gr...

The study was obtained to develop oral controlled release matrix tablets of Lamivudine having different proportion of Guar gum (retardant polymer) and to study the effect of formulation factor such as polymer proportion on the invitro release. The prepared granules were evaluated such as angle of repose, loose bulk density, tapped bulk density and compressibility index and satisfactory results ...

The present research concerns the formulation and evaluation of sustained release pellets filled capsule of opioid analgesic, Tramadol HCl. Development of sustained release dosage form is to maintain therapeutic blood levels of the drug for extended period of time. Sustained release formulation provides uniform concentration at absorption site, maintains plasma concentration within a therapeuti...

The expense and complications in new drug entities have increased since last 3 decades, with concomitant recognition of the therapeutic advantages of controlled drug delivery. So focus has been given on development of sustained or controlled release drug delivery systems. Bilayer tablet is new novel of tablet for the successful development of controlled release formulation along with various fe...

In this study calendering is used as a downstream technique to shape monolithic co-extruded fixed-dose combination products in a continuous way. Co-extrudates with a metoprolol tartrate-loaded sustained-release core and a hydrochlorothiazide-loaded immediate-release coat were produced and immediately shaped into a monolithic drug delivery system via calendering, using chilled rolls with tablet-...