•A-to-I editing is strongly induced 30–35 bp away from structural disruptions•A-to-I symmetrically introduced on opposing sites of a dsRNA•Structural disruptions by give rise to the next event•Distant mismatches increase targeted efficiency Adenosine-to-inosine catalyzed ADAR1 at thousands transcriptome-wide. Despite intense interest in physiological, bioengineering, and therapeutic perspective...