BACKGROUND Trimethylamine N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, has mechanistic links to atherosclerotic coronary artery disease (CAD) pathogenesis and is associated with adverse outcomes. OBJECTIVES This study sought to examine the relationship between plasma TMAO levels and the complexity and burden of CAD and degree of subclinical myonecrosis. METH...

The guidelines state a class III level of evidence (LoE) B recommendation against percutaneous coronary intervention (PCI) in patients with left main disease with a high SYNTAX score (> 32) and three-vessel disease with intermediate (23–32) and high SYNTAX scores. There appears to be insufficient evidence to support this recommendation, given the fact that this is based on only one trial (SYNTA...

BACKGROUND Coronary artery disease (CAD) is a global problem with increasing incidence in Asia. Prior studies reported inter-ethnic differences in the prevalence of CAD rather than the severity of CAD. The angiographic "synergy between percutaneous coronary intervention (PCI) with taxus and cardiac surgery" (SYNTAX) score quantifies CAD severity and predicts outcomes. We studied CAD severity an...

BACKGROUND AND OBJECTIVES The recently discovered myokine irisin has a proposed role in adipose tissue metabolism. The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD). SUBJECTS AND METHODS Sixty-three patients who underwent coronary angiography (CA) diagnosed with stable CAD an...