Background and Purpose: Soleshine is a polyherbal preparation established in the market for the treatment of cracks and tinea pedis, which is applied externally. This preparation is composed of the extracts of indigenous plants, namely Azadirachta indica, Lawsonia alba, and Shorea robusta, mixed with castor oil and sesame oil. In the present study, an attempt was made to identify the constituen...

Listeriosis, in particular that caused by Listeria monocytogenes, is a major foodborne pathogen, and its control is becoming difficult because of widespread emergence of drug resistance strains. Chorismate synthase (CS), an essential enzyme of shikimate pathway present only in bacteria, fungi, plant and some apicomplexan parasites, is a validated potential antimicrobial drug target. Antimicrobi...

Background: Cardiovascular disease is the leading cause of death in world. The therapeutic activity Monascus sp. pigment can act as an anticardiovascular agent. Research on rapidly developing, including discovery new pigments, methods used, and their identification. Currently, there are 57 dyestuff compounds that have been successfully isolated from molds. So, researchers conducted in-silico st...

Novel acrylamide and methacryloyl carrying piperazine-dihydrofuran derivatives (3a-p) were designed obtained from radical cyclizations of unsaturated piperazine (1a-f) with 1,3-dicarbonyl compounds (2a-c) mediated by Mn(OAc)3. Obtained characterized spectroscopic methods. In vitro AChE inhibitory activites 3a-p evaluated against (Acetylcholinesterase) Ellman method test results showed that 3a, ...

Introduction Oxidative stress plays an essential role in the pathogenesis of chronic diseases. Disrupting Keap1-Nrf2 pathway by binding Keap1 is identified as a potential strategy to prevent oxidative stress-related Therefore, special interest utilization dietary antioxidations from citrus, including narirutin, naringenin, hesperetin, hesperidin, naringin, neohesperidin dihydrochalcone, neohesp...

The purpose of this article is to synthesize some novel 1,8-Naphthyridine-3-Carboxylic acid derivatives, analyze them, and assess their antibacterial potential. With the help elemental analysis, IR, NMR, mass spectrum data, synthesized derivatives were identified. Derivatives' activity was determined using cup plate diffusion method. At doses 50 μg/ml 100 μg/ml, substance demonstrated substanti...

The accumulation of amyloid β peptide1-42 (Aβ1-42) masses in the brains of Alzheimer’s Disease (AD) patients is associated with neuronal loss and memory deficits. We have previously reported that oral administration of docosahexaenoic acid (DHA, C22:6, n-3) significantly decreases Aβ burden in the brains of AD model rats and that direct in vitro incubation of DHA with Aβ1-42 curbs the progressi...