in this study an easy, green, efficient and simple approach is reported for the synthesis of some benzothiazole-, benzimidazole- and benzoxazole-2-thiolderivatives. the proposed approach employs the reaction of corresponding aromatic amine with potassium isopropyl xanthate (z11) in the presence of copper sulfate (cuso4) as a catalyst under conventional heating and ultrasonic irradiation. the ad...

The synthesis and distribution of hyaluronate and proteoglycan were studied in bovine articular cartilage in short-term explant culture with [3H]acetate and H2(35)SO4 as precursors. The incorporation of [3H]acetate into hyaluronate and sulphated glycosaminoglycans was linear with time, except that hyaluronate synthesis showed a marked lag at the beginning of the incubation. [3H]Hyaluronate repr...

mycobacterium smegmatis ptcc 1307 (cip 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (add) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. the side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. an intermediate structure with intact side chain, cholest-4-ene-3-one, ...

The synthesis of 4-3H-labelled ketone bodies, and their use along with 14C-labelled ketone-body precursors, is employed using an 'in vivo' rat infusion model to measure ketone-body turnover. The use of two isotopes is necessary to measure ketone-body turnover when ketogenesis may occur from more than one precursor such as glucose and fatty or amino acids. Requirements of isotopic equivalence in...