نتایج جستجو برای: synthetic peptides vaccine

تعداد نتایج: 318649  

2015
Mark Kaddumukasa Catherine Lwanira Allan Lugaajju Elly Katabira Kristina E. M. Persson Mats Wahlgren Fred Kironde

INTRODUCTION There is no approved vaccine for malaria, and precisely how human antibody responses to malaria parasite components and potential vaccine molecules are developed and maintained remains poorly defined. In this study, antibody anamnestic or memory response elicited by a single episode of P. falciparum infection was investigated. METHODS This study involved 362 malaria patients aged...

Journal: :Infection and immunity 2000
S K Joshi A Bharadwaj S Chatterjee V S Chauhan

Liver-stage antigen 1 (LSA-1) is a potential vaccine candidate against preerythrocytic stages of malaria. We report here the immunogenicity of linear synthetic constructs delineated as T(H)-cell determinants from the nonrepeat regions of Plasmodium falciparum LSA-1 in murine models and human subjects from areas where malaria is endemic in Rajasthan State, India. Seven peptide constructs (LS1.1 ...

2017
Hongzhao Li Mikaela Nykoluk Lin Li Lewis R Liu Robert W Omange Geoff Soule Lukas T Schroeder Nikki Toledo Mohammad Abul Kashem Jorge F Correia-Pinto Binhua Liang Nancy Schultz-Darken Maria J Alonso James B Whitney Francis A Plummer Ma Luo

Cynomolgus macaques are an increasingly important nonhuman primate model for HIV vaccine research. SIV-free animals without pre-existing anti-SIV immune responses are generally needed to evaluate the effect of vaccine-induced immune responses against the vaccine epitopes. Here, in order to select such animals for vaccine studies, we screened 108 naïve female Mauritian cynomolgus macaques for na...

Introduction: The study of the effects of synthetic peptides with antibacterial properties can provide more effective antibiotics. This study designed, expressed, and investigated the Sushi 3 tetramer peptide. Subsequently, it was compared in terms of changing antibacterial properties with another Sushi3 tetramer peptide the aspartic acid and proline amino acids of which were replaced with glyc...

Journal: :Nature Reviews Drug Discovery 2018

2017
Jose Rojas-Caraballo Julio López-Abán Darwin Andrés Moreno-Pérez Belén Vicente Pedro Fernández-Soto Esther del Olmo Manuel Alfonso Patarroyo Antonio Muro

BACKGROUND Fasciolosis remains a significant food-borne trematode disease causing high morbidity around the world and affecting grazing animals and humans. A deeper understanding concerning the molecular mechanisms by which Fasciola hepatica infection occurs, as well as the molecular basis involved in acquiring protection is extremely important when designing and selecting new vaccine candidate...

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