It has long been recognized the epidemiological association of psoriasis, especially the most severe forms, with several diseases that share a common pathogenic substrate involving TNF-α and different target organs (arthritis and Crohn disease, for example), as well as an increased risk of coronary heart disease and occlusive cardiovascular disease. In the patient with severe psoriasis there is...

Systemic autoinflammatory disorders comprise an expanding group of rare conditions. They are mediated by dysfunction the innate immune system and share a core phenotypic manifestations including recurrent attacks fever, cutaneous signs, chest or abdominal pain, lymphadenopathy, vasculopathy, musculoskeletal symptoms. Diagnosis is often established in childhood, but growing number adult patients...