Key words: systemic sclerosis; scleroderma renal crisis; to complain of arthralgia affecting mainly her wrists sine scleroderma; sine hypertension and small joints of the hands. For the last several months she had experienced difficulty in swallowing and anorexia with a resultant weight loss of 20 kg. Despite these symptoms, she did not seek medical

The ocular manifestations of progressive systemic sclerosis (PSS) have been described by Manschot (i 965), Nelken and Michaelson (196 I), Pollack and Becker (1962), and Stucchi and Geiser (I967). These reports were mainly limited to isolated cases, although Stucchi and Geiser (i967) studied a series of fourteen patients-thirteen with generalized scleroderma and one in whom the scleroderma was c...

Although definitive answers are not yet forthcoming, understanding the mechanisms of fibrosis in scleroderma might improve the relative therapeutic vacuum now surrounding not only generalised scleroderma (systemic sclerosis (SSc)) but also the fibrosis of keloid formation, cirrhosis of the liver, pulmonary fibrosis, and atherosclerosis as well. Discussion here will include immune, vascular, and...

Dear Editor: We read with great interest the article by Touré and colleagues published in a recent issue of your journal, entitled " Antiphospholipid Antibodies and Systemic Scleroderma ". In this study, they investigated 40 patients with systemic scleroderma (SSc) for the presence of antiphospholipid antibodies (aPLs). Overall, they found aPLs in 23 (57.5%) patients. The most frequently encoun...

BACKGROUND AND PURPOSE Advanced cerebrovascular wall calcification was recently observed at autopsy in 2 patients with systemic sclerosis. To further investigate this issue, we conducted a prospective CT study of scleroderma patients to detect intracerebral calcification. METHODS Thirty-seven consecutive patients with systemic sclerosis underwent unenhanced brain CT. Images were blindly inter...