The production and economics of GIFT strain of tilapia (Oreochromis niloticus) reared in nine seasonal small ponds at Bangladesh Agricultural University campus for a period of three months during August to October were evaluated. The experiment was arranged in three treatments (T) each with three replications. The ponds were drained, limed and fertilized with organic and inorganic fertilizers d...

Type 3 iodothyronine deiodinase (D3) catalyzes the conversion of T4 and T3 to inactive metabolites. It is highly expressed in placenta and thus can regulate circulating fetal thyroid hormone concentrations throughout gestation. We have cloned and expressed a 2.1-kb human placental D3 cDNA which encodes a 32-kD protein with a Km of 1.2 nM for 5 deiodination of T3 and 340 nM for 5' deiodination o...

This study evaluated the prognostic value of thyroid-related hormones within normal ranges after acute ischemic stroke. This was a retrospective study and we reviewed 1072 ischemic stroke patients consecutively admitted within 72 h after symptom onset. Total triiodothyronine (T3), total thyroxine (T4), free T3, free T4, and thyroid-stimulating hormone (TSH) were assessed to determine their valu...

Conducting pharmacokinetic (PK) studies in pregnant women is challenging. Therefore, we asked if a physiologically based pharmacokinetic (PBPK) model could be used to evaluate different dosing regimens for pregnant women. We refined and verified our previously published pregnancy PBPK model by incorporating cytochrome P450 CYP1A2 suppression (based on caffeine PK) and CYP2D6 induction (based on...

We examined the effect of endogenous free fatty acids (FFA) on the measurement of free thyroxin (FT4) by five different methodologies represented in 16 different assays in a large number of patients with nonthyroidal illness (NTI). Some, but not all, one-step (analog) FT4 RIAs negatively correlated with FFA concentration. All two-step FT4 RIAs, equilibrium dialysis FT4, and the dialyzable (free...

This study reports the development of a highly sensitive and reproducible RIA for the measurement of 3,5-diiodothyronine (3,5-T2) in human serum and tissue. The RIA employs 3-bromo-5-[125I]iodo-L-thyronine (3-Br-5-[125I]T1) as tracer, which was synthesized carrier free by an interhalogen exchange from 3,5-dibromo-L-thyronine (3,5-Br2T0). The detection limits were 1.0 fmol/g and 0.8 pmol/L in hu...

BACKGROUND & OBJECTIVES There is scarcity of information on impact of iodine deficiency on growth and development of newborns, both pre-term and term babies. The present study was carried out to see the impact of iodine deficiency (ID) on the intrauterine foetal growth and development in terms of birth weight (BW) in an African population living in an iodine deficient zone. METHODS The matern...

CONTEXT RTHα is a recently discovered resistance to thyroid hormone (RTH) due to mutation of THRA, the gene encoding TRα1, the thyroid hormone receptor. It has been described in a few patients with growth retardation, short stature, and a low free T4/free T3 (FT4/FT3) ratio. OBJECTIVE A 27-year-old patient presenting with dwarfism and a low FT4/FT3 ratio was investigated. DESIGN Clinical, b...

N AUTOMATED TECHNIQUE for the determination of serum T31 uptake, based on the AutoAnalyzer, was proposed by Pollard et al. (1); a report of the clinical application of this method followed (2) and minor technical improvements were reported by Webber et al. (3). The latter showed an excellent correlation between the T3 uptake as measured by the automated technique and serum PBI. Continued experi...

A total of 60 Russ 2011 two weeks old broiler chicks with an average weight of 215.33+4.55g were fed with diets compounded with sweet potato leaves (SPL) for 56 days. The diets consist of T1 (0% SPL), T2 (5% SPL), T3 (10% SPL) and T4 (15% SPL). The proximate composition of the SPL was determined in the laboratory. The birds were randomly allocated to four treatments using completely randomized ...