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تعداد نتایج: 145 فیلتر نتایج به سال:
Background/Aims MicroRNAs (miRNAs) play critical regulatory roles in the pathogenesis of pulmonary fibrosis. The aim this study was to explore whether miRNA antagomirs could serve as potential therapeutic agents interstitial lung diseases. Methods A mouse model fibrosis established by intratracheal injection bleomycin (BLM). Using microarray analysis, up-regulated miRNAs were identified during ...
At least eight types of ubiquitin chain exist, and individual linkages affect distinct cellular processes. The only distinguishing feature of differently linked ubiquitin chains is their structure, as polymers of the same unit are chemically identical. Here, we have crystallized Lys 63-linked and linear ubiquitin dimers, revealing that both adopt equivalent open conformations, forming no contac...
Signaling by tumor necrosis factors (TNFs) plays a prominent role in mammalian development and disease. To fully understand this complex signaling pathway it is important to identify all regulators and transduction components. A single TNF family member, Eiger, is encoded in the Drosophila genome, offering the possibility of applying genetic approaches for pursuing this goal. Here we present a ...
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