نتایج جستجو برای: tab2

تعداد نتایج: 145  

Journal: :The Korean Journal of Internal Medicine 2021

Background/Aims MicroRNAs (miRNAs) play critical regulatory roles in the pathogenesis of pulmonary fibrosis. The aim this study was to explore whether miRNA antagomirs could serve as potential therapeutic agents interstitial lung diseases. Methods A mouse model fibrosis established by intratracheal injection bleomycin (BLM). Using microarray analysis, up-regulated miRNAs were identified during ...

Journal: :EMBO reports 2009
David Komander Francisca Reyes-Turcu Julien D F Licchesi Peter Odenwaelder Keith D Wilkinson David Barford

At least eight types of ubiquitin chain exist, and individual linkages affect distinct cellular processes. The only distinguishing feature of differently linked ubiquitin chains is their structure, as polymers of the same unit are chemically identical. Here, we have crystallized Lys 63-linked and linear ubiquitin dimers, revealing that both adopt equivalent open conformations, forming no contac...

Journal: :Genetics 2005
Peter Geuking Rajesh Narasimamurthy Konrad Basler

Signaling by tumor necrosis factors (TNFs) plays a prominent role in mammalian development and disease. To fully understand this complex signaling pathway it is important to identify all regulators and transduction components. A single TNF family member, Eiger, is encoded in the Drosophila genome, offering the possibility of applying genetic approaches for pursuing this goal. Here we present a ...

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