Introduction. Microcos paniculata is traditionally used for treating diarrhea, wounds, cold, fever, hepatitis, dyspepsia, and heat stroke. Objective. To investigate the qualitative phytochemical constituents of hydromethanol (HMPB) and petroleum benzene extract of Microcos paniculata barks (PBMPB) and to evaluate their antinociceptive and antidiarrheal activities. Methods. Phytochemical constit...

Aims: The pain caused by peripheral nerve neuropathy is one of the most frequent complaints of diabetic patients. Nowadays, researchers are looking for new extracts of therapeutic herbs as a cure for diabetic hyperalgesia due to lack of proper and safe medications. Cyanidin is a potent antioxidant and anti-inflammatory agent, which reduces oxidative stress and also plays an anti-diabetic role i...

In folk medicine Mallotus repandus (Willd.) Muell. Arg. is used to treat muscle pain, itching, fever, rheumatic arthritis, snake bite, hepatitis, and liver cirrhosis. This study aimed to evaluate the antinociceptive as well as the anti-inflammatory activities of the methanol extract of leaf. The leaves were extracted with methanol following hot extraction and tested for the presence of phytoche...

Secondary metabolites from plants are a good source for the NSAID drug development. We studied the analgesic activity of ethanolic extract of Erythrina variegata L. (Fabaceae) followed by molecular docking analysis. The analgesic activity of Erythrina variegata L. is evaluated by various methods viz., acetic acid-induced writhing test, hot plate and tail immersion test. Subsequently, molecular ...

BACKGROUND Cyperus rotundus Linn. (Cyperaceae) is used to treat inflammation, pain, fever, wounds, boils and blisters in folk medicine. This study evaluated the antinociceptive effect of the hydromethanol extract of whole plant of C. rotundus (HMCR). METHODS The antinociceptive activity of HMCR was investigated in thermal-induced (hot plate and tail immersion) and chemical-induced (formalin) ...

BACKGROUND Vanda tessellata (Orchidaceae) has been used in different sorts of ailments such as inflammations, rheumatism, dysentery, bronchitis, dyspepsia and fever in folk medicine. In this study we evaluated the antinociceptive and cytotoxic effect of methanol and aqueous extracts of V. tessellata leaf. METHODS Oral administration of V. tessellata aqueous (VTA) and methanol (VTM) leaf extra...

Surfactants are frequently used to improve solubilization of lipophilic drugs. Cremophor EL (CrEL) is a polyoxyethylated castor oil surfactant used to solubilize water-insoluble drugs such as anesthetic, antineoplastic, immunosuppressive and analgesic drugs, vitamins and new synthetic compounds, including potential analgesics. The antinociceptive effect of CrEL (3.2, 6.4 and 10.6 g/kg, in 10 ml...

Immersive virtual environments (VEs) have often been described as a technology looking for an application. Part of the reluctance from industry to make regular use of immersive VEs stems from the fact that there is no empirical evidence suggesting that immersive applications provide any benefit over non-immersive ones. We present a method in this paper that can be used to statistically support ...

To elucidate the mechanism of anti-arthritic action of the Arthosansar, a polyherbal formulation has proven anti-arthritic activity. The mechanism is elucidated by emphasizing on immunomodulation, anti-inflammatory and analgesic action. The study is carried out using CFA induced arthritis in rats, carrageenan induced peritonitis in mice, inflammation induced by various phlogistic agents in rats...

Hydroxydihydrocarvone (HC) is a synthetic intermediate obtained by hydration of the natural compound (R)-(-)-carvone. The aim of the present study was to investigate the possible anti-inflammatory activity of orally administered HC. Toxicity, motor coordination, tail immersion test, as well as carrageenan-induced paw edema and myeloperoxidase (MPO) activity or peritonitis were all evaluated in ...