Hij = K ·Rij ·K−1. Here Rij denotes a column-wise permutation of R, shuffling the columns i and j to be column 1 and 2. 1.1. Computing y4 from y1, y2 and y3 Let a be a known aspect ratio defined as w/h, where h is the height and w the width of the front wall in the physical world (we know these dimensions from the rental site). Then, given two corner points p1 and p2 of a wall, defined by the t...

Introduction Conclusions References

We study the duality between M-theory compactified on Calabi-Yau fourfolds and the heterotic string compactified on Calabi-Yau threefolds times a circle. Our analysis is based on a comparison of the low energy effective actions in three dimensions. Non-perturbative N=1 vacua of the heterotic string in D=4 are of particular interest due to their phenomenological prospects [1]. A certain class of...

OBJECTIVE The aim of this study was to investigate the relation between the polymorphism of large molecular weight proteasome (LMP) (LMP2-LMP7) and transporter associated with antigen processing (TAP) (TAP1-TAP2) genes and rheumatoid arthritis (RA). METHODS Sixty RA patients and 102 ethnically matched unrelated healthy subjects were typed for LMP, TAP, and disease associated HLA-DRB1 alleles ...

TAP proteins (transporters associated with antigen processing) take part in the transport of oligopeptides created in proteasomes from cytoplasm into endoplasmic reticulum. In the endoplasmic reticulum those oligopeptides are bound to MHC class I molecules and transported to the cell surface. TAP proteins consist of two subunits: TAP1 and TAP2. It has been previously shown that TAP protein expr...

PURPOSE Human leukocyte antigen (HLA) class I antigen defects, which are frequently present in head and neck squamous cell carcinoma (HNSCC) cells may provide the tumor with an escape mechanism from immune surveillance. Scanty information is available about mechanisms underlying HLA class I antigen defects in both lesions and cell lines from HNSCC. In this study, we investigate the role of anti...

We hypothesize that over-expression of transporters associated with antigen processing (TAP1 and TAP2), components of the major histocompatibility complex (MHC) class I antigen-processing pathway, enhances antigen-specific cytotoxic activity in response to viral infection. An expression system using recombinant vaccinia virus (VV) was used to over-express human TAP1 and TAP2 (VV-hTAP1,2) in nor...

Type I and type II interferons (IFNs) are cytokines that establish the cellular antiviral state through the induction of IFN-stimulated genes (ISGs). We sought to understand the basis of the antiviral activity induced by type I and II IFNs in relation to the functions of their ISGs. Based on gene expression studies, we systematically identified antiviral ISGs by performing blinded, functional s...