We describe the design and operationalization of a blinded corticosteroid-tapering regimen for a randomized trial of tocilizumab in giant cell arteritis (GCA). To our knowledge, no clinical trial in any disease has ever employed a blinded corticosteroid-tapering regimen, but this was necessary to the design of our trial which is likely to be relevant to other investigations of steroid-sparing r...

Increment threshold for a small (e.g. 1' x 5') line target superimposed on backgrounds of various shapes and sizes was measured to provide a detailed map of the spatial interactions about line targets. This modified "Westheimer paradigm" indicated sensitization in the length direction as well as in the width direction around the line target. The effect of the adaptation field summed over an elo...

Cefepime is a fourth-generation cephalosporin that covers gram-positive bacteria and gram-negative bacteria, such as Pseudomonas. A 48-year-old male patient underwent posterior tibial artery perforator-based fasciocutaneous turnover flap was administered cefepime. After 2 days, the showed neurological symptoms, cognitive decline aphasia. We immediately stopped cefepime changed to ciprofloxacin....

Acute febrile neutrophilic dermatosis (Sweet syndrome) is a potentially fatal multiorgan inflammatory disease characterized by fever, leukocytosis, and rash with infiltrate. Disease pathophysiology remains elusive. Corticosteroids steroid sparing agents remain mainstays of treatment, but refractory cases pose clinical challenge. Whole genome sequencing transcriptomic profiling Sweet syndrome pa...

AIMS The study aimed at comparing the fixed tapering dose and the symptom-triggered regimens of lorazepam for alcohol detoxification. METHODS We carried out a prospective, randomized, double blind controlled trial involving 63 consecutive consenting male patients admitted with diagnosis of uncomplicated alcohol withdrawal. The patients were randomized into two groups based on the type of lora...

Parameters identified to reduce and eliminate micro-hole sidewall tapering in nickel alloy C263.

OBJECTIVES The goal of this study was to assess whether a platelet rebound exists and whether it can be attenuated by clopidogrel tapering. BACKGROUND Clinical studies have reported a clustering of thrombotic events after stopping clopidogrel treatment. The hypothesis of a rebound phenomenon of platelets has been declared causative, but its existence has never been confirmed. Tapering of clop...