Mycobacterium tuberculosis complex (MTBC) infections are treated with combinations of antibiotics; however, these regimens not as efficacious against multidrug and extensively drug resistant MTBC. Phenotypic (growth-based) susceptibility testing on slow growing bacteria like MTBC requires many weeks to months complete, whereas sequencing-based approaches can predict resistance (DR) reduced turn...

BackgroundNext-generation sequencing (NGS) is increasingly used for clinical evaluation of cardiomyopathy patients as it allows simultaneous screening multiple cardiomyopathy-associated genes. Adding copy number variant (CNV) analysis NGS data not routine yet and may contribute to the diagnostic yield.ObjectivesDetermine yield our targeted gene panel in diagnostics Dutch explore impact exon CNV...