نتایج جستجو برای: tau

تعداد نتایج: 20923  

Journal: :The Journal of biological chemistry 2012
Xiaomin Yin Nana Jin Jianlan Gu Jianhua Shi Jianhua Zhou Cheng-Xin Gong Khalid Iqbal Inge Grundke-Iqbal Fei Liu

Tau exon 10, which encodes the second microtubule-binding repeat, is regulated by alternative splicing. Its alternative splicing generates Tau isoforms with three- or four-microtubule-binding repeats, named 3R-tau and 4R-tau. Adult human brain expresses equal levels of 3R-tau and 4R-tau. Imbalance of 3R-tau and 4R-tau causes Tau aggregation and neurofibrillary degeneration. In the present study...

2017
Ivan Koychev Roger N. Gunn Azadeh Firouzian Jennifer Lawson Giovanna Zamboni Basil Ridha Barbara J. Sahakian James B. Rowe Alan Thomas Lynn Rochester Dominic Ffytche Robert Howard Henrik Zetterberg Clare MacKay Simon Lovestone

BACKGROUND Combining PET amyloid-β (Aβ) and tau imaging may be critical for tracking disease progression in Alzheimer's disease (AD). OBJECTIVE We sought to characterize the relationship between Aβ and tau ligands as well as with other measures of pathology. METHODS We conducted a multi-center observational study in early AD (MMSE >20) participants aged 50 to 85 y. The schedule included cog...

Journal: :Brain : a journal of neurology 2003
Prudence M Stanford Claire E Shepherd Glenda M Halliday William S Brooks Peter W Schofield Henry Brodaty Ralph N Martins John B J Kwok Peter R Schofield

The majority of cases with frontotemporal dementia (FTD) have no tau deposition in the brain, yet mutations in the tau gene lead to a similar clinical phenotype with insoluble tau depositing in neuropathological lesions. We report two tau gene mutations at positions +19 and +29, in the intronic sequences immediately following the stem loop structure in exon 10, which segregate with FTD. Exon-tr...

2018
Norimichi Shirafuji Tadanori Hamano Shu-Hui Yen Nicholas M Kanaan Hirotaka Yoshida Kouji Hayashi Masamichi Ikawa Osamu Yamamura Masaru Kuriyama Yasunari Nakamoto

Increased plasma homocysteinemia is considered a risk factor of dementia, including Alzheimer's disease (AD) and vascular dementia. However, the reason elevated plasma homocysteinemia increases the risk of dementia remains unknown. A pathological hallmark of AD is neurofibrillary tangles (NFTs) that consist of pathologically phosphorylated tau proteins. The effect of homocysteine (Hcy) on tau a...

2012
Vanessa Plouffe Nguyen-Vi Mohamed Jessica Rivest-McGraw Johanne Bertrand Michel Lauzon Nicole Leclerc

It is well established that tau pathology propagates in a predictable manner in Alzheimer's disease (AD). Moreover, tau accumulates in the cerebrospinal fluid (CSF) of AD's patients. The mechanisms underlying the propagation of tau pathology and its accumulation in the CSF remain to be elucidated. Recent studies have reported that human tau was secreted by neurons and non-neuronal cells when it...

Journal: :Journal of Alzheimer's disease : JAD 2011
Donna M Barten Gregory W Cadelina Nina Hoque Lynn B DeCarr Valerie L Guss Ling Yang Sethu Sankaranarayanan Paul D Wes Marianne E Flynn Jere E Meredith Michael K Ahlijanian Charles F Albright

Levels of tau in cerebrospinal fluid (CSF) are elevated in Alzheimer's disease (AD) patients. It is believed this elevation is related to the tau pathology and neurodegeneration observed in AD, but not all tauopathies have increased CSF tau. There has been little pre-clinical work to investigate mechanisms of increased CSF tau due to the difficulty in collecting CSF samples from mice, the most ...

2010
Stephanie J. Adams Michael A. DeTure Melinda McBride Dennis W. Dickson Leonard Petrucelli

Tauopathies are defined by assembly of the microtubule associated protein tau into filamentous tangles and classified by the predominant tau isoform within these aggregates. The major isoforms are determined by alternative mRNA splicing of exon 10 generating tau with three (3R) or four (4R) approximately 32 amino acid imperfect repeats in the microtubule binding domain. In normal adult brains t...

2014
Sergio Camero María J. Benítez Raquel Cuadros Félix Hernández Jesús Ávila Juan S. Jiménez

Tau hyperphosphorylation can be considered as one of the hallmarks of Alzheimer's disease and other tauophaties. Besides its well-known role as a microtubule associated protein, Tau displays a key function as a protector of genomic integrity in stress situations. Phosphorylation has been proven to regulate multiple processes including nuclear translocation of Tau. In this contribution, we are a...

2013
Amy M Pooler Emma C Phillips Dawn H W Lau Wendy Noble Diane P Hanger

Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown. We show that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from healthy, mature cortical neurons. Notably, phosphorylation of extracellular tau appears reduced in comparison with intracellular tau. We also find that...

2006
Neelam Shahani Srinivasa Subramaniam Tobias Wolf Christian Tackenberg Roland Brandt

Alzheimer’s disease (AD) is characterized by progressive loss of neurons in selected brain regions, extracellular accumulations of amyloid , and intracellular fibrils containing hyperphosphorylated tau. Tau mutations in familial tauopathies confirmed a central role of tau pathology; however, the role of tau alteration and the sequence of tau-dependent neurodegeneration in AD remain elusive. Usi...

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