Materials and methods: Ninety pigs (9.42 ± 0.05 kg) were used in a study with five dietary treatments: an uncontaminated control diet with no additives and four similar diets that were contaminated with 500 ng per g aflatoxin B1 (AB1) and supplemented with no additive, with 0.5% HSCAS, with an antioxidant preparation providing 125 mg per kg of ethoxyquin and 10 mg per kg of TBHQ, or with both H...

The antioxidant activities of TBHQ, BHT and tocopherol mixtures at different concentrations (0, 100, 200, 400 mg/kg) have been evaluated by the application of Differential Scanning Calorimetry (DSC) and Rancimat apparatus. Rancimat apparatus that measures the secondary oxidation products was set at 110 ⁰C with an air flow of 18-20 L/h to measure the induction period (IP) of the samples. The DSC...

The brain is a very susceptible organ to structural and functional alterations caused by oxidative stress and its vulnerability increases with age. Understanding the antioxidant response activated by the transcription factor Nrf2 has become very important in the aging field in order to activate cellular protection. However, the role of Nrf2 inducers during old age has not been completely unders...

NF-E2 related factor-2 (NRF2) is an essential transcription factor for multiple genes encoding antioxidants and detoxification enzymes. NRF2 is implicated in promoting cancer therapeutic resistance by its detoxification function and crosstalk with proproliferative pathways. However, the exact mechanism of this intricate connectivity between NRF2 and growth factor induced proliferative pathway r...

RESUMO: O trabalho teve como objetivo avaliar o potencial antioxidante do extrato de Curcuma longa L. na estabilidade oxidativa óleo soja. Para isso, os tratamentos Controle (óleo soja), TBHQ100 soja com 100 mg TBHQ/kg), Extrato100 β-caroteno extrato/kg) e TBHQ50+Extrato50 50 TBHQ/kg + foram submetidos ao teste acelerado em estufa (60 ºC/20 dias). apresentou 51,17% atividade pelo método DPPH• 9...

In line with the application of green techniques in recovery bioactive compounds, this research study aimed to evaluate efficiency supercritical Co2 and water distillation extraction sweet basil essential oil. addition, effect wall material made native gums as well Lepidium sativum (LS), perfoliatum (LP), a combination both (LP/LS), following freeze-drying method, on Nano-emulsion properties en...

DNA microarrays can be classified into oligonucleotides (Affymetrix) or long cDNAs (IncyteGenomics) based on the arrayed probes. Unfortunately, data are lacking on the comparison of these two popular global screening array systems. The present study was designed to assess the reliability of datasets generated by the two platforms from the same samples. We have already established a model for up...

Past efforts to employ a structure-based approach to design an inhibitor of the fusion-inducing conformational change in the influenza virus hemagglutinin (HA) yielded a family of small benzoquinones and hydroquinones. The most potent of these, tert-butyl hydroquinone (TBHQ), inhibits both the conformational change in HA from strain X:31 influenza virus and viral infectivity in tissue culture c...