Background: Invasive lobular and ductal breast tumors have distinct histologies clinical presentation. cancer (ILC) characteristics include somatic alterations in the CDH1 gene leading to loss of E-cadherin expression, low HER2 frequent PTEN, increased AKT expression mutations PIK3CA, TBX3 FOXA1 genes. cancers (IDC) express more often HER2+ ESR1 mutations. The XenoSTART Patient-Derived Xenograf...