CD101, a transmembrane glycoprotein involved in the T cell activation, has been reported as core signature of human CD8+ resident memory (TRM) cells, but not CD4+ TRM cells. However, CD101 expression examined skin Thus, was determined both epidermal and dermal cells using noninflamed skin. Inconsistent with previous report, highly expressed tended higher than CD103+ CD103− Besides CD4 CD8 major...

Metallic materials are always suffered from the risk of combustion when serviced under some extreme conditions such as high temperature, oxygen-enriched enrichment, and high-speed friction. Although different mathematic models have been proposed but it is still a challenge for accurately describing ignition metals conditions, which great significance safety-use materials. In this paper, based o...

Psoriasis is a chronic inflammatory skin disease characterized by hyperplasia of keratinocytes and immune cell infiltration. The IL-17-producing T cells play key role in psoriasis pathogenesis, while regulatory (Treg) are diminished during psoriatic inflammation. Current treatments largely focus on IL-17 IL-23, however, few studies have explored therapeutic drugs targeting an increase Treg to c...

Background: TFF1 deficiency induces a mucosal pro-inflammatory phenotype that contributes to gastric tumorigenesis in mouse and human. Methods: We utilized the Tff1-KO mouse model to assess the impact of TFF1 loss on immune cells infiltration in the stomach. We used single cell suspension, flow cytometry, immunohistochemistry, and quantitative PCR (qPCR) assays. Results: The Tff1-KO gastric muc...