Mutations in the intermediate filament (IF) protein desmin cause severe forms of myofibrillar myopathy characterized by partial aggregation of the extrasarcomeric desmin cytoskeleton and structural disorganization of myofibrils. In contrast to prior expectations, we showed that some of the known disease-causing mutations, such as DesA360P, DesQ389P and DesD399Y, are assembly-competent and do al...

Abstract: The Quasi-static mechanical properties of hybrid fiber (steel fiber and Polyvinyl alcohol (PVA) fiber) reinforced cementitious composites (HFRCC(SP)) were investigated by compressive and tensile experiments. The compressive strength, peak strain, elastic modulus and tensile strength are studied as compared with that of engineered cementitious composite (ECC). Study results indicate th...

Tensile specimens of nonflammable AZ91D Mg alloy were fabricated in this study via cold chamber die-casting process. Dimensions of tensile specimens were 25mm in length, 4mm in width, and 0.8 or 3.0mm in thickness. Microstructure observation was conducted before and after tensile tests at room temperature. In the die casting process, various injection distances from 150 to 260mm were employed t...

A self-developed rotary multi-cutter device cuts stainless steel wire ropes into segments to fabricate twisted wires. Stainless steel porous twisted wire materials (PTWMs) with a spatial composite intertexture structure are produced by the compaction and subsequent vacuum solid-phase sintering of twisted wires. The stainless steel PTWMs show two types of typical uniaxial tensile failure modes, ...

Estimating mechanical properties of concrete before designing reinforced concrete structures is among the design requirements. Steel fibers have a considerable effect on the mechanical properties of reinforced concrete, particularly its tensile strength. So far, numerous studies have been done to estimate the relationship between tensile strength of steel fiber reinforced concrete (SFRC) and ot...

The present work deals with the utilization of oil palm mesocarp fibre (OPMF) and poly(butylene succinate) (PBS) to produce cost-effective biodegradable materials. The biocomposite was prepared from OPMF and PBS at a weight ratio of 70:30 via a melt blending technique without addition of any additive. This biocomposite showed relatively low tensile and water resistance properties. As a conseque...

This study focuses on the effect of the amount of silica fume addition and volume fraction of steel fiber on the engineering properties of cementitious materials. Test variables include dosage of silica fume (5% and 10%), water/cement ratio (0.35 and 0.55) and steel fiber dosage (0.5%, 1.0% and 2.0%). The experimental results included: compressive strength, direct tensile strength, splitting te...

Purpose The purpose of this study was to characterize the relation between corneal hydration and stiffening effects of the UVA/riboflavin collagen crosslinking treatment and to investigate how artificially swelling the cornea prior to this treatment procedure affects tensile property improvement. Methods Porcine corneas were collagen crosslinked in vitro at different hydration levels using a ...

Using uniaxial tensile and hardness testing, we evaluated the variability and anisotropy of the mechanical properties of an austenitic stainless steel, UNS S17400, manufactured by an additive process, selective laser melting. Like wrought materials, the mechanical properties depend on the orientation introduced by the processing. The recommended stress-relief heat treatment increases the tensil...