BACKGROUND It is known that following chronic dosing with bupropion HCl active metabolites are present in plasma at levels that are several times higher than that of the parent drug, but the possible convulsive effects of the major metabolites are not known. METHODS We investigated the convulsive liability and dose-response of the three major bupropion metabolites following intraperitoneal ad...

INTRODUCTION Concurrent hairy cell leukemia (HCL) and chronic lymphocytic leukemia (CLL) is rare; management is inadequately described in the literature. METHODS Retrospective chart review and clinical follow-up. RESULTS Five patients are described. The first patient developed synchronous HCL and CLL and was treated with rituximab for 13 months with HCL in remission and stable CLL. The seco...

An efficient green chemistry approach to the synthesis of N-substituted piperidones and piperidines was developed and applied to the synthesis of 1-(2-pyridinylmethyl)-piperidin-4-one, 1, a key starting material for the synthesis of LY317615, an antiangiogenic agent currently under development at Eli Lilly and Company (Chart 1).(1) The general utility of this methodology, which presents signifi...

After a frog tongue was adapted to 0.001 M quinine-HCl(Q-HCl), a change in the gustatory neural responses to salts was investigated. The initial phasic response to a variety of salt solutions such as 0.1 M NaCl, KCl, LiCl, MgCl2 and CaCl2 was greatly potentiated as a result of the Q-HCl adaptation. A weaker enhancement of the response to salts was observed after the tongue was adapted to deioni...

Infrared–ultraviolet double resonance has been used to photodissociate the free HCl bond of the HCl dimer. This creates Cl–HCl in a coherent superposition of electronic and vibrational states. Measurement of the translational energy of the departing H atom using high-n Rydberg time-of-flight spectroscopy enables the Cl–HCl potential surfaces to be probed. The features thus obtained agree with t...

AIMS To know the prevalence and the interaction among the principal cardiovascular risk factors such as hypercholesterolemia (HCL), hypertension (HTA), overweight, carbohydrates metabolism disturbances, and smoking, an urban survey was performed in the six Mexican Republic states, where the national population is more concentrated. METHODS This survey was transversally designed using the WHO ...