نتایج جستجو برای: terfenadine
تعداد نتایج: 282 فیلتر نتایج به سال:
The KCNH2 and KCNE2 genes encode the cardiac voltage-gated K+ channel KV11.1 and its auxiliary β subunit KCNE2. KV11.1 is critical for repolarization of the cardiac action potential. In humans, mutations or drug therapy affecting the KV11.1 channel are associated with prolongation of the QT intervals on the ECG and increased risk of ventricular tachyarrhythmia and sudden cardiac death--conditio...
1. The effects of several CYP3A substrates (alpha-naphthoflavone (alphaNF), terfenadine, midazolam, erythromycin) on nifedipine oxidation and testosterone 6beta-hydroxylation activities were investigated in hepatic and intestinal microsomes from mouse and human. 2. alphaNF (10 microM) and terfenadine (100 microM) inhibited nifedipine oxidation activities (at substrate concentration of 100 micro...
Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC (R.Z., G.M.P.); Drug Disposition, Eli Lilly and Company, Indianapolis, IN 46285 (J.C.K.); Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC (S.B.Y., A.S.B.) DMD Fast Forward. Published on D...
diseases mainly mediated by a type I allergic reaction. Pharmacological studies have demonstrated that oxatomide acts as an antagonist for various chemical mediators such as histamine, leukotriene and platelet-activating factor, as well as inhibits the release of these substances, and that all these actions contribute to therapeutic effects of the drug. Oxatomide is widely applied to skin disea...
There is immense pressure on all developers of new drugs today to efficiently and costeffectively produce compounds with efficacies better than existing therapies and with very limited adverse effects. This requires the simultaneous optimization of both the desired bioactivity and the absorption, distribution, metabolism, excretion and toxicity (ADMET) properties of a drug candidate. Of the ADM...
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