Substrate specificity and pH dependence of the transport system for diphenhydramine were investigated in Caco-2 cell monolayers. Diphenhydramine uptake was not affected by any typical substrate for the renal organic cation transport system except procainamide. Along with procainamide, tertiary amine compounds with N-dimethyl or N-diethyl moieties in their structures inhibited the diphenhydramin...

The curing process of epoxy and amine mixtures was investigated from the viewpoint molecular size reactants via all-atom dynamics simulation. Of four composed either smaller or larger molecules, system both reached highest conversion at a given time, whereas for combination lowest. These can be explained in terms their diffusion coefficients. In addition, effect on reaction kinetics more striki...

Phenyl a-aminoketones have been shown to undergo carbon skeleton rearrangement to unconjugated aminoketones when heated a t 200-240". The probable intermediate is an unconjugated hydroxyimine formed by base removal of an amine hydrogen and migration of an alkyl group. The hydroxyimine can subsequently rearrange by base removal of a hydroxyl proton and migration of the phenyl grouping. An amine ...

In the structure of the title compound, [HgCl2(C12H20N2)], the Hg(II) atom has a distorted tetra-hedral coordination sphere defined by two tertiary amine N-atom donors, as well as two Cl(-) anions [the dihedral angle between the N-Hg-N and Cl-Hg-Cl planes is 82.80 (9)°]. The five-membered chelate ring adopts an envelope conformation, with puckering parameters of Q(2) = 0.446 (6) Å and ϕ(2) = 88...

Four pharmaceuticals (ranitidine, nizatidine, doxylamine, and carbinoxamine) were selected as model compounds to assess the efficiency of four oxidants (ozone (O3), chlorine (Cl2), chlorine dioxide (ClO2) and potassium permanganate (KMnO4)) on the removal of amine-based pharmaceutical and personal care products (PPCPs), as well as the reduction of their N-Nitrosodimethylamine formation potentia...

Epoxies are often cured using primary and secondary amines in an efficient reaction catalyzed by tertiary amines. Through coordination effects, lower the transition-state energy enough to allow take place under ambient conditions. In this paper, we demonstrate how, conditions, bound close intramolecular proximity a amine able catalyze amine-epoxy reactions as well promote etherifications epoxy-...

Interior tertiary amine groups of PAMAM-OH dendrimers (hydroxyl-terminated polyamidoamine, PAMAM) were modified by methylation to make these polymers have a more cationic character, which enabled electrostatic interaction between PAMAM-OH and plasmid DNA. A methylation reaction was dose-dependent, producing internally quaternized PAMAM-OH (QPAMAM-OH), thereby making tertiary amine/quaternary am...

A novel biointerface bearing zwitterionic carboxybetaine moieties was developed for effective resistance to nonspecific adsorption of proteins and blood cells. Self-assembled thin films (SAFs) of (N,N-dimethylaminopropyl) trimethoxysilane were formed as mattress layers by either vapor or solution deposition. Subsequently, the tertiary amine head groups on SAFs were reacted with β-propiolactone ...

In this study, the host-guest behavior of poly(amidoamine) (PAMAM) dendrimers bearing amine, hydroxyl, or carboxylate surface functionalities were investigated by paramagnetic NMR studies. 2,2,6,6-Tetramethylpiperidinyloxy (TEMPO) derivatives were used as paramagnetic guest molecules. The results showed that TEMPO-COOH significantly broaden the ¹H NMR peaks of amine- and hydroxyl-terminated PAM...

Diamines covalently coupled to glass substrates promoted human foreskin fibroblast adhesion in the absence of serum. These diamine-derivatized substrates were produced by coupling ethylene diamine, N-methylaminoethylamine, and N,N-dimethylaminoethylamine (NNDMAEA), to sulfonyl chloride-activated glass. Electron spectroscopy for chemical analysis demonstrated that the diamines were coupled via t...