abstract in the present set of investigations, the anti-mutagenic and anti-cytotoxic effects of aqueous rosemary leaves extract (re) beside the dose dependency of these effects on male mice bone marrow and germ cells have been evaluated using in vivo cytogenetic, histopathologic and apoptotic assays, as well as biochemical analysis. doxorubicin (dxr), a well-known mutagen and cytotoxic agent, w...

AIM To evaluate the effects of melatonin on antioxidant enzyme levels and histopathologic changes in dizocilpine (MK-801)-induced psychosis model rat testis. METHODS A total of 24 adult male Wistar-Albino rats were divided into three groups with 8 in each. Group I was used as control. Rats in Group II were injected with MK-801 (0.5 mg/kg body weight i.p. for 5 days). In addition to MK-801, me...

Reactive oxygen species (ROS) and reactive nitrogen (RNS) play a fundamental role in regulating endothelial function vascular tone the physiological conditions of system. However, oxidative stress has detrimental effects on human health, numerous studies confirmed that high ROS/RNS production contributes to initiation progression cardiovascular diseases. The antioxidant defense an essential hom...

Objectives: Cinnamon as an antioxidant is able to reduce oxidative stress. Previous study confirmed antioxidant enzymes have beneficial and essential effects on male infertility by their role against reactive oxygen species. Material and methods: Wistar male rats (n=20) were allocated into two groups, control group (n=10) and cinnamon group (n=10) that received 75mg/kg by gavage method, daily f...

Background & Aims: Para-Nonylphenol (p-NP) can cause oxidative stress through reducing the activity of scavenging enzymes. The aim of the present study was to investigate the effect of green tea extract, as an antioxidant, on testisin rats exposed to p-NP. Methods: In the present study, 24 Wistar rats with mean body weight of 215 ± 10 g were divided into 4 groups (n = 6)...