BACKGROUND Clinical recognition of tularemia is essential for prompt initiation of appropriate antibiotic treatment. Although fluoroquinolones have desirable attributes as a treatment option, limited data on efficacy in the US setting exist. METHODS To define the epidemiology of tularemia in Missouri, and to evaluate practices and outcomes of tularemia management in general, we conducted a de...

The quantification of antibiotics (ABs) in sediments is an analytical challenge, but at the same time, it indispensable to understand fate ABs aquatic systems such as rivers. aim this study was develop a comprehensive method determine 19 classified macrolides, sulfonamides, fluoroquinolones, tetracyclines, clindamycin and trimethoprim river sediments, using combination pressurized liquid extrac...

Abstract Objectives Data on consumption of tetracyclines, sulphonamides and trimethoprim, other antibacterials were collected from 30 EU/European Economic Area (EEA) countries over two decades. This article reviews temporal trends, seasonal variation, presence change-points changes in the composition main subgroups trimethoprim antibacterials. Methods For period 1997–2017, data tetracyclines (A...

FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic effects in association with macrolides, ofloxacin, and rifampin.

The occurrence and distribution of 19 antibiotics including ten sulfonamides, four quinolones, three tetracyclines and two macrolides in water, sediment, and biota samples from the Liao River Basin, China were investigated in the present study. The samples were collected in May 2012, and laboratory analyses revealed that antibiotics were widely distributed in the Liao River Basin. Macrolides ma...

Since their discovery in 1945, tetracyclines have been used extensively in the therapy and prophylaxis of infectious diseases and as growth promoters. These wide applications have led to the equally fast spread of tetracycline resistant strains of gram-positive and gram-negative bacterial genera, including strains belonging to pathogenic as well as nonpathogenic species. Nonpathogenic bacteria ...

By studying the literature about tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are well known, especially against bacteria, while against other targets, they are virtually unknown. In other diverse fields of research-such as neurology, oncology and virology-the utility and activity of the tetracycl...

The inhibitory potency of four classes of compounds that inhibit corneal ulceration (thiols, tetracyclines, sodium citrate and sodium ascorbate) was assessed with collagenase purified from culture medium of alkali-burned rabbit corneas. The most potent inhibitor, a beta-mercaptomethyl tripeptide HSCH2(DL)CH[CH2CH(CH3)2]CO-Phe-Ala-NH2, exhibited 50% inhibition (IC50) at approximately 10 nM using...

This study was based on the hypothesis that the occurrence of antimicrobial residues and antibiotic resistant bacteria in the sewage could be correlated with the structure and composition of the bacterial community and the antibiotic resistance loads of the final effluent. Raw and treated wastewater composite samples were collected from an urban treatment plant over 14 sampling dates. Samples w...

The in vitro activity of various antibiotics against Pseudomonas pseudomallei was studied. The tetracyclines were the most active, followed by gentamicin, kanamycin, novobiocin, chloramphenicol, rifampin, cycloserine, erythromycin, and ampicillin.