Telocytes (TCs) represent a new distinct type of interstitial cells found in many organs, including lungs. TCs are mainly defined by a small cellular body from which arise very long (hundreds of micrometers) extensions named telopodes. During the last years, TCs were characterized in respect with their microRNA profiles, gene features and proteome signatures. Also, the ultrastructural 3D config...

The substantial use of triclosan (TCS) has been aimed to kill pathogenic bacteria, but TCS resistance seems to be prevalent in microbial species and limited knowledge exists about TCS resistance determinants in a majority of pathogenic bacteria. We aimed to evaluate the distribution of TCS resistance determinants in major pathogenic bacteria (N = 231) and to assess the enrichment of potentially...

This study systematically investigated the ocean mixed layer responses to tropical cyclone (TC) using available Argo profiles during the period of 1998–2011 in the northwest Pacific. Results reveal that isothermal layer (IL) deepening and isothermal layer (IL) cooling with evident rightward biases induced by strong TCs are clearer compared to the weak TCs. Likewise, the rightward biases of IL d...

Telocytes (TCs) are a peculiar type of interstitial cells with very long prolongations termed telopodes. TCs have previously been identified in different anatomic structures of the heart, and have also been isolated and cultured from heart tissues in vitro. TCs and fibroblasts, both located in the interstitial spaces of the heart, have different morphologies and functionality. However, other th...

Trichosanthin (TCS), an active protein component isolated from a traditional Chinese medicinal herb Trichosanthes kirilowii, has been shown to inhibit HIV infection and has been applied in clinical treatment of AIDS. The recent development that chemokines and chemokine receptors play important roles in HIV infection led us to investigate the possible functional interaction of TCS with chemokine...

Sepsis was induced by cecal ligation.Chemically modified tetracyclines CMTs are derivatives of tetracycline group of drugs which lack antimicrobial action but have potent host modulating affects.Chemically Modified Tetracyclines: An Emerging Host Modulatory Therapy. 1Sonakshi Gupta and 2 Vidya Dodwad. 1Postgraduate student III Yr, Department.of chemically modified tetracyclines CMTs on the prod...

Tetracyclines are broad spectrum antibiotic, belong to the family of polyketide antibiotic ,produced by Streptomyces aureofaciens of actinobacteria. The organism Streptomyces aureofaciens 325 was obtained MTCC and cultured on the starch casein media. Screening the organism for the production was confirmed by antibiogram test. The production media was optimized by using carbon sources, and nitro...

BACKGROUND Telocytes (TCs) are a novel type of interstitial cells, which have been recently described in a large variety of cavitary and noncavitary organs. TCs have small cell bodies, and remarkably thin, long, and moniliform prolongations called telopodes (Tps). Until now, TCs have been found in various loose connective tissues surrounding the arterioles, venules, and capillaries, but as a hi...

The neuroprotective properties of tetracyclines have been clearly established in rodent models of acute and chronic neurodegeneration during the past few years. Recent findings have provided novel insights into the molecular and cellular mechanisms of protection of neurons and oligodendrocytes by tetracyclines. These advances have prompted several clinical trials with minocycline, the most effe...

Early sensory experience shapes the anatomy and function of sensory circuits. In the mouse olfactory bulb (OB), prenatal and early postnatal odorant exposure through odorized food (food/odorant pairing) not only increases the volume of activated glomeruli but also increases the number of mitral and tufted cells (M/TCs) connected to activated glomeruli. Given the importance of M/TCs in OB output...