نتایج جستجو برای: tetrameric 1
تعداد نتایج: 2754421 فیلتر نتایج به سال:
One of the β-glucosidases from Pyrococcus furiosus (BGLPf) is found to be a hyperthermophilic tetrameric enzyme that can degrade cellooligosaccharides. Recently, the crystal structures of the tetrameric and dimeric forms were solved. Here, a new monomeric form of BGLPf was constructed by removing the C-terminal region of the enzyme and its crystal structure was solved at a resolution of 2.8 Å i...
A mutant pyruvate kinase (ATP:pyruvate 2-O-phosphotransferase, EC 2.7.1.40) from human erythrocytes which is easily separated into monomers and dimers by gel chromatography is described. Tht mutant enzyme shows almost the same pH optimum and thermostability as normal enzyme, but has a decreased stability on shaking with air, a decreased Km for phosphoenolpyruvate and a loss of allosteric proper...
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8 1 T cells. These ‘expansions’, which are commonly detected in the peripheral blood, can persist during chronic HIV infection and may result in the dominance of particular clones. Such clonal populations are most consistent with antigen-drive...
Yeast aldehyde dehydrogenase and each of two of its active proteolytic digestion products are readily dissociable into subunits which can, in turn, reassociate. The native protein dissociates into four subunits of equal sire. The partially digested enzymes dissociate into the same subunit plus a second, smaller subunit. The data are interpreted in terms of a tetrameric native enzyme, differing ...
Tryptase, a 135kDa tetrameric serine protease, was originally isolated from lung mast cells (MC). This enzyme is stored in and released from MC granules upon activation. Tryptase is an exquisite marker in heterogeneous populations of MC, allowing for their differentiation from basophils. Because tryptase is the principal protein mediator component of mast cell granules, accounting for 23% of th...
Little is known of the changes in human immunodeficiency virus type 1 (HIV-1)-specific effector cytotoxic T lymphocytes (CTL) after potent antiretroviral therapy. Using HLA/peptide tetrameric complexes, we show that after starting treatment, there are early rapid fluctuations in the HIV-1-specific CTL response which last 1 to 2 weeks. These fluctuations are followed by an exponential decay (med...
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