Prevalence of β-thalassemia is high amongst the genetic disorders of hemoglobin synthesis. Frequency of β-thalassemia trait is about 5-6% in Pakistan. β-thalassemia major is characterized by severe hemolytic anemia that requires regular blood transfusion. Life expectancy of these patients is strikingly prolonged with repeated blood transfusion and iron chelation therapy but consequences associa...

Low plasma levels of total cholesterol (TC) with or without hypertriglyceridemia have been frequently described in a variety of hematologic disorders in which anemia is a prominent feature.2,3 It is well established that β-thalassemia is associated with changes in plasma lipids and lipoproteins. In β-thalassemia major, low cholesterol levels caused by a significant reduction of both low-density...

It has recently been estimated that each year, more than seven million babies worldwide are born with either a congenital abnormality or a genetic disease.1 Hemoglobinopathies are the commonest autosomal hereditary disorders and present a major public health problem in India. The overall prevalence of the -thalassemia trait is 2.78% but this varies from 1.48 to 3.64% in different states of Indi...

Premarital screening (PMS) can be an important tool to detect of carriers of hemoglobinopathies. The aim of this study was to assess the knowledge and attitude of premarital couples about Thalassemia before PMS in Denizli province. This cross-sectional study was conducted between August-December 2013. The target population was all premarital couples who applied to the City Hemoglobinopathy Cont...

Sickle cell anemia (SCA) is a disease characterized by abnormal red blood rheology. Because of their effects on HbS polymerization and deformability, alpha-thalassemia the residual HbF level are known genetic modifiers disease. The aim our study was to determine if number quantitative trait loci (QTL) would also favor specific sub-phenotype SCA as it case for alpha-thalassemia. Our results conf...

Background: Studies have demonstrated that sickle cell trait can be found in an asymptomatic healthy carrier with normal complete blood count (CBC) and red blood cell (RBC) indices. According to Iranian Ministry of Health bulletin instructions, prenuptial Thalassemia Screening Program (TSP) primarily depends on RBC indices which are measured through a routine CBC. Only when these levels are bel...

CLINICAL MANIFESTATIONS OF INHERITED ABNORMAL HEMOGLOBINS. I. THE / \. INTERACTION OF HEMOGLOBIN-S WITH HEMOGLOBIN-D. II. INTERACTION / OF HEMOGLOBIN-E AND THALASSEMIA TRAIT Phillip Sturgeon, Harvey A. Itano and William R. Bergren 389 STUDIES ON ABNORMAL HEMOGLOBINS. XI. SICKLE CELL-THALASSEMIA DISEASE IN THE NEGRO. THE SIGNIFICANCE OF THE S + A + F AND S -4A PATTERNS OBTAINED BY HEMOGLOBIN ANA...

To determine whether hemoglobin E trait influences the antimalarial effect of artemisinin derivatives, we retrospectively compared 32 case patients with hemoglobin E trait to 32 control patients who did not have hemoglobin E, beta-thalassemia, glucose-6-phosphate dehydrogenase deficiency, or alpha-thalassemia trait on the basis of a mean corpuscular volume > or =78 femtoliters. All patients wer...