In the experimental group (shh inhibited group), there were significant decreases in the expression of Oct4, Nanog, Shh, GATA4, Brachyury and Goosecoid, while increases were observed for TAT and Pdx1. The expression of Sox17 did not differ between two control and experimental groups. In experimental group, the amount of GSC positive cells was somehow lower but it seems that there was no differe...

Apoptotic pathways are providing important saveguard mechanisms in protection from cancer by eliminating altered and often harmful cells. The disturbances of cell proliferation, differentiation and apoptosis are also found on specific signal-transduction pathways within the tumour cells and between these and the immune system. The article focuses attention on the evolution of the melanocytic na...

In this paper, we present a new software package, TAT, that allows the statistical study of the IP traffic transmitted trough an Internet node. This tool has been successfully tested under a work carried out in a subnet of the regional network of Murcia (Spain) called Ciez@net. Cieza is a village of 30,000 people where the pilot network Ciez@net intends to bring these people the opportunity to ...

Although projective techniques continue to be widely used in clinical and forensic settings, their scientific status remains highly controversial. In this monograph, we review the current state of the literature concerning the psychometric properties (norms, reliability, validity, incremental validity, treatment utility) of three major projective instruments: Rorschach Inkblot Test, Thematic Ap...

Surgery induces immediate hypercoagulability by direct alteration of the vascular bed, release of procoagulant substances from the extravascular spaces and blood flow decrease, and delayed hypercoagulation in response to tissue damage which triggers inflammatory responses. Thus, the postoperative period represents a high-risk time for thrombosis. Recognition of high-risk individuals would make ...

published their groundbreaking monograph " The achievement motive " in 1953, scientific research on human motives such as the needs for achievement, affiliation, or power was off to a great start as a respectable, promising and flourishing branch of psychology. It generated thousands of published research reports over the next three decades and spilled over into other disciplines such as politi...

Let (N) denote a mean-eld measure with potential F. Asymptotic independence properties of the measure (N) are investigated. In particular, with H(j) denoting relative entropy, if there exists a unique non{degenerate minimum of H(j) ? F(), then propagation of chaos holds for blocks of size o(N). Certain degenerate situations are also studied. The results are applied for the Langevin dynamics of ...

OBJECTIVES The coagulation and fibrinolytic system appears to be activated by the septic process independently, leading to the syndrome of disseminated intravascular coagulation (DIC). In this study, we investigated the changes within the hemostatic system related to the severity of the illness and the prognosis in patients with sepsis. METHODS Plasma thrombin-antithrombin III (TAT) and plasm...

an HIV regulatory protein called Tat, to three other products. IAVI President Seth Berkley agreed to work with AVIP to " strengthen the European effort, " with no special emphasis on Italian research, he says. " We won't do it otherwise, " says Berkley, adding that " anything we do would be subject to our scientific review methods. " Although Ensoli's Tat vaccine is but one part of AVIP, some r...

BACKGROUND AND OBJECTIVES It has been reported that the influence of plasma fibrinogen on the incidence of myocardial infarction is related to inflammatory processes. The aim of this study was to investigate the relationship between inflammatory activity, fibrinogen and thrombin generation in patients 5 years after the acute phase of myocardial infarction. DESIGN AND METHODS Sixty-seven patie...