Acoustic cavitation can occur in therapeutic applications of high-amplitude focused ultrasound. Studying acoustic cavitation has been challenging, because the onset of nucleation is unpredictable. We hypothesized that acoustic cavitation can be forced to occur at a specific location using a laser to nucleate a microcavity in a pre-established ultrasound field. In this paper we describe a scient...

Ultrasound-targeted microbubble destruction (UTMD) is a promising technique for non-invasive, targeted drug delivery, and its applications in chemotherapeutic drug delivery to solid tumors have attracted growing interest. Ultrasound, which has been conventionally used for diagnostic imaging, has evolved as a promising tool for therapeutic applications mainly because of its ability to be focused...

BACKGROUND Therapeutic ultrasound is one of several rehabilitation interventions suggested for the management of pain due to patellofemoral pain syndrome. OBJECTIVES To assess the effectiveness and side effects of ultrasound therapy for treating patellofemoral pain syndrome. SEARCH STRATEGY We searched MEDLINE, Embase, Healthstar, Sports Discus, CINAHL, the Cochrane Controlled Trials Regist...

When exposed to sufficiently high ultrasound pressures, microbubbles can be generated spontaneously in tissue and undergo inertial cavitation where collapses result in physical effects. These effects range from petechial haemorrhage to complete cellular disruption, termed Histotripsy, depending on ultrasound parameters. This presentation will explore the mechanisms associated with histotripsy a...

BACKGROUND AND PURPOSE Physiological effects of therapeutic ultrasound (US) are dependent on the intensity and duration of application. The purpose of this study was to test US machines used in clinical settings for proper calibration of time and power output. METHODS Measurements of power output and timer accuracy were obtained from 83 US units in clinical use. The machines were tested at 4 ...

Introduction: Low-intensity doses of ultrasound are currently used in the treatment of various musculoskeletal conditions. However, this ultrasonic therapy may be contraindicated in children due to the potential for growth disturbances, particularly at the epiphyseal plates of the long bones. We hypothesize that current clinical therapeutic doses of ultrasound (0.5 W/cm2) will not cause prematu...