OBJECTIVE To introduce pharmacists to the process, challenges, and opportunities of creating transitions of care (TOC) models in the inpatient, ambulatory, and community practice settings. METHODS TOC literature and resources were obtained through searching PubMed, Ovid, and GoogleScholar. The pharmacist clinicians, who are the authors in this manuscript are reporting their experiences in the...

Titer on Chip (Flu-ToC) is a new technique for quantification of influenza hemagglutinin (HA) concentration. In order to evaluate the potential of this new technique, a comparison of Flu-ToC to more conventional methods was conducted using recombinant HA produced in a baculovirus expression system as a test case. Samples from current vaccine strains were collected from four different steps in t...

The Mollisols from the Pampas Region of Argentina have been described as presenting different compactability behaviors under agricultural systems. The purpose of this study was to provide information on the inherent soil factors related to the susceptibility to compaction. Total organic carbon (TOC), texture (CLAY, SILT, SAND), water retention at 0.33 kPa (WR), Proctor maximum bulk density (BDM...

We used coupled watershed and reservoir models to evaluate the impacts of deforestation and l Niño Southern Oscillation (ENSO) phase on drinking water quality. Source water total organic carbon (TOC) is especially important due to the potential for production of carcinogenic disinfection byproducts (DBPs). The Environmental Fluid Dynamics Code (EFDC) reservoir model is used to evaluate the diff...

This paper aims to introduce System Dynamics (SD) in applying Drum Buffer Rope (DBR) methodology of Theory of Constraints (TOC) in a three-stage flow shop system that produces a single product. To the best of our knowledge, although there are a lot of TOC applications using discrete simulation in production scheduling with DBR methodology, there are not any TOC application of DBR methodology in...

UNLABELLED In this investigation, the efficacy of scintigraphy using (99m)Tc-labeled hydrazinonicotinyl-Tyr3-octreotide (HYNIC-TOC) in the evaluation of extraadrenal pheochromocytoma was assessed and compared with (131)I-labeled metaiodobenzylguanidine (MIBG) imaging. METHODS Ninety-seven patients who were suspected of having pheochromocytoma but showed no definite adrenal abnormalities on CT...

BACKGROUND In current practice, patients scheduled for radiotherapy are treated according to 'rigid' protocols with predefined dose prescriptions that do not consider risk-taking preferences of individuals. The therapeutic operating characteristic (TOC) graph is applied as a decision-aid to assess the trade-off between treatment benefit and morbidity to facilitate dose prescription customisatio...

We evaluated the effects of alpha-Toc on surface expression of CD11b/CD18 on polymorphonuclear leukocytes (PMN) stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP) and oxidized low-density lipoprotein (oxLDL). Incubation of PMN with fMLP (1 microM) or oxLDL (100 microg/mL) increased CD11b/CD18 expression; pretreatment with alpha-Toc reduced in a dose-dependent manner. PMN obtained fr...

Ferulic acid (FA) and tocopherol (Toc) loaded solid lipid nanoparticles (SLN) were prepared by a hot homogenisation method. The particle size distribution, zeta potential and melting behaviour of the SLN as well as the stability, encapsulation efficiency and radical scavenging activity of FA and Toc in the SLN were analysed. The different formulations containing up to 2.8 mg g-1 of FA or Toc we...

BACKGROUND There is little practical guidance on how contextually relevant mental healthcare plans (MHCPs) can be developed in low-resource settings. AIMS To describe how theory of change (ToC) was used to plan the development and evaluation of MHCPs as part of the PRogramme for Improving Mental health carE (PRIME). METHOD ToC development occurred in three stages: (a) development of a cross...