We present herein a new and efficient four-component synthesis of isoxazol-5(2H)-ones involving ring closing/Knoevenagel condensation/Michael addition sequential reactions.

The cover feature image illustrates two mail devices, drones (representing sprayed microdroplets) and in-person bulk phase), to deliver a letter the Petasis reaction involving aldehydes, arylboronic acids amines) in sharply different efficiencies. This study supplies not only mild, efficient environmentally friendly methodology constructing aryl amines organic community but also useful derivati...