نتایج جستجو برای: thrombophilic gene
تعداد نتایج: 1141932 فیلتر نتایج به سال:
Venous thromboembolism, which includes deep vein thrombosis and pulmonary embolism, is the result of an imbalance among procoagulant, anticoagulant and profibrinolytic processes. This imbalance reflects a complex interplay between genetic and environmental or acquired risk factors. Genetic thrombophilic defects influence the risk of a first episode of thrombosis. How these defects influence the...
Introduction: Recurrent pregnancy loss (RPL) is defined as two or more consecutive which occurs before the 20th weeks of pregnancies for last menstrual period. Hereditary cause thrombophilic gene mutations and polymorphism may play an essential role in RPLs. Material Method: 291 women with a history abortions study group 61 without miscarriages control were included study. In this we analysed e...
BACKGROUND AND OBJECTIVES The clinical expression of factor V Leiden varies widely within and between families and only a minority of carriers will ever develop venous thromboembolism. Co-segregation of thrombophilic disorders is a possible explanation. Our aim was to assess the contributions of high levels of factor VIII:C, factor XI:C, thrombin activatable fibrinolysis inhibitor (TAFI) and li...
BACKGROUND Venous thromboembolism (VTE) and subclinical thyroid dysfunction (SCTD) are both common in elderly patients. SCTD has been related to a hypercoagulable state and an increased thromboembolic risk. However, prospective data on the relationship between SCTD and VTE are lacking. OBJECTIVES To investigate the relationship between SCTD and recurrent VTE (rVTE), all-cause mortality, and t...
OBJECTIVE To estimate whether parental thrombophilic defects after fetal death, either acquired or inherited, were more prevalent than in the normal population and to estimate associations between these thrombophilic defects and different fetal death causes. METHODS In a multicenter, prospective cohort study of 750 fetal deaths, we tested couples for antithrombin, protein C, total and free pr...
BACKGROUND HIV-infected patients are at increased risk of venous and arterial thrombosis. We hypothesized that acquired thrombophilic abnormalities that could predispose to thrombosis are most pronounced in patients in advanced stages of HIV infection. METHODS We included 109 consecutive HIV-infected patients in the study and tested them twice for currently known thrombophilic abnormalities a...
Over the past years, there has been a dramatic increase in the number of identifiable causes of thrombophilia. However, to date, there are no large, prospective studies to assess an optimal, cost-effective approach with regard to screening and case finding for thrombophilic risk factors in patients presenting with retinal vessel occlusion. Two hundred twenty-eight patients with retinal vein occ...
We compared the efficiency of real-time PCR analysis FII (c.*97G>A, G20210A) and FV Leiden (c.1601G>A) thrombophilic mutations in samples obtained from venous blood treated with various anticoagulant agents (EDTA, heparin, sodium fluoride potassium oxalate), or clotted blood; one hundred wild-type subjects were tested. Genomic DNA extracts whole specimens modified by 90 °C heating analys...
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