نتایج جستجو برای: thrombophilic markers
تعداد نتایج: 223187 فیلتر نتایج به سال:
Schlembach and co-workers in this issue of Clinical Science have studied the association of maternal and/or fetal factor V Leiden (FVL) and prothrombin G20210A gene mutation with HELLP syndrome and intrauterine growth restriction (IUGR) to confirm whether these genetic mutations are important risk factors for the pathogenesis of the HELLP syndrome, leading to an inadequate maternal-fetal circul...
The term thrombophilia refers to an abnormality of blood coagulation that increases the risk of thrombosis. Such abnormalities represent one component of the triad (along with stasis and abnormalities of the vessel wall) put forward by Virchow in the 19th century to explain why thrombosis occurs. Thrombophilic abnormalities may be heritable (the topic of this review) or acquired, although both ...
Neonatal cerebral sinovenous thrombosis (CSVT) is a rare disease with severe neu rological sequelae. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate cycle, and mutations in MTHFR are associated with vascular diseases. Here, we report the case of a newborn with MTHFR mutationassociated CSVT. Analysis of MTHFR in the patient detected heterozygous C677T (677CT) and A129...
Common inherited thrombophilic defects such as factor V Leiden and G20120A mutation of the prothrombin gene interact synergistically with oral contraceptives to increase the risk of venous thromboembolism. 2 The best approach to identify women at higher risk of venous thromboembolism before taking oral contraceptives is controversial. Universal screening is not cost effective because 8000 women...
The recently discovered JAK2 V617F point mutation, found in 50-60% of ET patients, has been reported to be associated with a higher risk of thrombotic events. In this study, we explored if JAK2 V617F mutation, or coexisting thrombophilic and hemostatic risk factors, contributed to these complications. We examined 32 patients with ET, and looked for pathogenetic JAK2 V617F mutation and prothromb...
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