Thymic epithelial tumors occur in 1-5% of patients with multiple endocrine neoplasia type 1 (MEN 1). Majority of these thymic epithelial tumors are thymic carcinoids and patients with thymoma in MEN 1 is rare. Furthermore, thymoma with neuroendocrine differentiation was also rarely reported. Herein, we report a 68-year-old man having type B3 thymoma with neuroendocrine differentiation in MEN 1 ...

The normal human thymus originates from the third branchial cleft as two paired anlages that descend into thorax and fuse on midline of anterior–superior mediastinum. Alongside epithelial lymphoid components, different types accessory cells, stromal mesenchymal endothelial cells migrate to, or develop in, thymus. After reaching maximum development during early postnatal life, decreases in size ...

BACKGROUND The current study correlates cytologic morphology with histologic type and describes immunophenotypes with a focus on epithelial, neuroendocrine, and lymphoid characteristics in an institutional series of surgically excised thymomas. METHODS Fine needle aspirates (FNAs) and surgical specimens were retrospectively analyzed, and immunohistochemical stains were performed for EMA, cyto...

Using murine monoclonal antibodies TE-4 and TE-7 raised against human thymic stroma, we identified two distinct and mutually exclusive thymic microenvironment components: the thymic endocrine epithelium (TE-4+) and mesodermal-derived fibrous stroma (TE-7+). TE-4-reactive epithelium did not react with antibody TE-7, contained thymosin alpha 1 and keratin, and expressed other known markers of thy...

primary ureteral neoplasms are very rare and its prevalence is less than 1% of all genitourinary neoplasms. we report a symptomatic giant ureteral fibro epithelial polyp in adult women presenting as a bladder mass which was resected ureteroscopically and reported at the first time from iran. cystoscopy is growing use in the treatment of urinary tract lesions cystoscopy can be used in large lesi...

Thymic epithelial cells (TECs) are the main component of the thymic stroma, which supports T-cell proliferation and repertoire selection. Here, we demonstrate that Cbx4, a Polycomb protein that is highly expressed in the thymic epithelium, has an essential and non-redundant role in thymic organogenesis. Targeted disruption of Cbx4 causes severe hypoplasia of the fetal thymus as a result of redu...

Abstract The thymus is composed of thymocytes and stromal cells including thymic epithelial mesenchymal cells. Thymic are originated from Neural Crest (NC) the mesoderm. Although it known that NC-derived (NCd) contribute to organogenesis development, their specific role in T cell regeneration unclear. To evaluate regenerative ability NCd thymus, we used lethally irradiated mice examine effect i...

Natural CD4CD25 regulatory T lymphocytes are key protagonists in induction and maintenance of peripheral T cell tolerance. Their thymic origin and biased repertoire continue to raise important questions on the signals that mediate their development. We validated analysis of MHC class II-capture by developing thymocytes from thymic stroma as a tool to study quantitative and qualitative aspects o...

background: thymomas are rare epithelial tumors arising from thymus gland. this study aims at investigating the clinical presentation, prognostic factors and treatment outcome of forty five patients with thymoma and thymic carcinoma. methods: forty-five patients being histologically diagnosed with thymoma or thymic carcinoma that were treated and followed-up at a tertiary academic hospital duri...