OBJECTIVE This paper describes the design, microfabrication, electrical characterization and biological evaluation of a high-density micro-needle array. The array records from and electrically stimulates individual neurons simultaneously in acute slices of brain tissue. APPROACH Acute slices, arguably the closest in-vitro model of the brain, have a damaged surface layer. Since electrophysiolo...

Purpose: To test a prototype Magnetic Resonance Imaging (MRI) compatible focused ultrasound phased array system for trans-skull brain tissue ablation using ex vivo human skulls and an animal model. Methods: Rabbit thigh muscle (N=3) and brain (N=10) were sonicated with a prototype, hemispherical 500element ultrasound phased array operating at frequencies between 700 and 800 kHz. An ex vivo huma...

background: development of tissue engineering and regenerative medicine has led to designing scaffolds and their modification to provide a better microenvironment which mimics the natural niche of the cells. gelatin surface modification was applied to improve scaffold flexibility and cytocompatibility. methods: plla/pcl aligned fibrous scaffold was fabricated using electrospinning method. adscs...

In the recent years, the optimization techniques using evolutionary algorithms have been widely used to solve electromagnetic problems. These algorithms use thinning the antenna arrays with the aim of reducing the complexity and thus achieving the optimal solution and decreasing the side lobe level. To obtain the optimal solution, thinning is performed by removing some elements in an array thro...

BACKGROUND Prostate cancer and benign prostatic hyperplasia are very common diseases in older American men, thus having a reliable treatment modality for both diseases is of great importance. The currently used treating options, mainly surgical ones, have numerous complications, which include the many side effects that accompany such procedures, besides the invasive nature of such techniques. F...

The aim of this study was to test a prototype MRI-compatible focused ultrasound phased array system for trans-skull brain tissue ablation. Rabbit thigh muscle and brain were sonicated with a prototype, hemispherical 500-element ultrasound phased array operating at frequencies of 700-800 kHz. An ex vivo human skull sample was placed between the array and the animal tissue. The temperature elevat...

This paper presents the results of acoustic field distribution simulations for 1024-element ultrasonic ring array intended diagnosis female breast tissue with use ultrasound tomography. For purpose analysing data, all fields created by each elementary transducer were combined. The natural position focus inside was changed altering activation time individual transducers in sectors consisting 32,...

A novel lens-array based illumination design for a compact co-registered photoacoustic/ultrasound transvaginal probe has been demonstrated. The lens array consists of four cylindrical lenses that couple the laser beams into four 1-mm-core multi-mode optical fibers with optical coupling efficiency of ~87%. The feasibility of our lens array was investigated by simulating the lenses and laser beam...

reversible logic circuits have found emerging attentions in nanotechnology,optical computing, quantum computing and low power design. a programmablelogic array (pla) is a universal circuit which is used to implement combinationallogic circuits. the main part of a pla is its and array. in this study we propose twotypes of optimized reversible programmable logic array (rpla) circuits. the firstty...