نتایج جستجو برای: tissue inhibitor matrix metalloproteinase 1
تعداد نتایج: 3736052 فیلتر نتایج به سال:
Background. Myocardial fibrosis is identified as a major side effect of Diabetes Mellitus on the heart. Some bio-markers including the ratio of matrix metalloproteinases and their inhibitors in collagen synthesis and collagen degradation are clinically useful in the diagnosis and identification of myocardial fibrosis. In addition, regular aerobic exercise training is one of the major and non-ph...
BACKGROUND Matrix Metalloproteinase functions in the remodeling of the extracellular matrix that is integral for many normal and pathological processes such as morphogenesis, angiogenesis, tissue repair, and tumor invasion. The tissue inhibitor of the metalloproteinase family including the tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates the activity of multifunctional metalloproteina...
Tissue inhibitor of metalloproteinase 1 (TIMP1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1 GPI) shifts the activity of TIMP-1 from the extracellular matrix to the cell surface. TIMP-1 GPI treated renal cell carcinoma cells show increased apoptosis and reduced proliferation. Transcriptom...
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