A finite-element approach was formulated, aimed at enabling an integrated study of mechanical and biochemical factors that control the functional development of tissue engineered constructs. A nonlinear biphasic displacement-velocity-pressure description was combined with advective and diffusive solute transport, uptake and biosynthesis. To illustrate the approach we focused on the synthesis an...

Predicting the virulence of new Influenza strains is an important problem. The solution to this problem will likely require a combination of in vitro and in silico tools that are used iteratively. We describe the agent-based modeling component of this program and report preliminary results from both the in vitro and in silico experiments.

Nowadays on medical and healthcare areas, training and learning methods for surgeons are based on skills development. In order to improve this learning process, virtual reality simulators have been proposed due its capacity to reproduce surgical procedures without any risk or harm on patient. These devices represent a wide research area that involves multiple fields of knowledge, such as mechat...

For investigations of electromagnetic field distributions in biological structures by Finite Element Method (FEM), a method for automatic 3D model building of human anatomical objects is developed. Models are made by meshed structures and specific electromagnetic material properties for each tissue type. Mesh is built according to specific FEM criteria for achieving good solution accuracy. Seve...

Our approach to tissue modeling incorporates biologically derived primitives into a computational engine (CellSim) coupled with a genetic search algorithm. By expanding an evolved synthetic genome CellSim is capable of developing a virtual tissue with higher order properties. Using primitives based on cell signaling, gene networks, cell division, growth, and death, we have encoded a 64-cell cub...

We present a multiscale method for the simulation of large viscoelastic deformations and show its applicability to biological tissue such as plant tissue. At the microscopic level we use a particle method to model the geometrical structure and basic properties of individual cells. The cell fluid, modeled as a viscoelastic fluid by means of Smoothed Particle Hydrodynamics (SPH) is enclosed in an...

A stable and accurate deformable model to simulate the deformation of soft tissues is a challenging area of research. This paper describes a soft tissue simulation method that can deform multiple organs synchronously and interact with virtual surgical instruments accurately. The model we used in our method is a multi-organ system by point masses and springs. The organs that anatomically connect...

The role of modeling in designing new treatment protocols and instruments is discussed. A computer program for modeling laser-tissue interaction named Latis is described. Interactions are divided into the processes of laser propagation, thermal effects, material effects, and hydrodynamics. Full coupling of the processes is taken into consideration. Applications in photothermal and photomechanic...

1 General Issues in Surgery Simulation 2 1.1 Surgical Simulators . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1.1 Medical Impact of Surgical Simulators . . . . . . . . . . . 2 1.1.2 Classi cation of Surgical Simulators . . . . . . . . . . . . 3 1.2 Simulator Architecture . . . . . . . . . . . . . . . . . . . . . . . . 4 1.2.1 Geometric Modeling . . . . . . . . . . . . . . . . . . . ....

Human body 3D scanners are becoming a mature technology that generates accurate static photo-realistic 3D models of real human beings. However the data collected allow only the construction of the outer surface of the body. In this paper we describe how from 3D surface data we generate 3D volumetric meshes of soft tissues suitable for the finite element method (FEM). We then deform these meshes...