The optimal mechanical properties of a scaffold to promote cartilage generation in osteochondral defects in vivo are not known. During normal daily activities cartilage is subjected to large cyclic loads that not only facilitate nutrient transport and waste removal through the dense tissue but also act as a stimulus to the chondrocytes. In contrast, cartilage tissue is commonly engineered in vi...

The GalaFLEX Scaffold (Galatea Surgical, Inc., Lexington, MA) for plastic and reconstructive surgery belongs to a new generation of products for soft tissue reinforcement made from poly-4-hydroxybutyrate (P4HB). Other members of this new family of products include MonoMax Suture (Aesculap AG, Tuttlingen, Germany) for soft tissue approximation, BioFiber Scaffold (Tornier, Inc., Edina, MN) for te...

A significant challenge to orthopaedic soft tissue repair is the biological fixation of autologous or allogeneic grafts with bone, whereby the lack of functional integration between such grafts and host bone has limited the clinical success of anterior cruciate ligament (ACL) and other common soft tissue-based reconstructive grafts. The inability of current surgical reconstruction to restore th...

Tissue engineering has provided an alternative therapeutic possibility for degenerative disc diseases. However, we lack an ideal scaffold for IVD tissue engineering. The goal of this study is to fabricate a novel biomimetic biphasic scaffold for IVD tissue engineering and evaluate the feasibility of developing tissue-engineered IVD in vitro and in vivo. In present study we developed a novel int...

To determine if an absorbable collagen scaffold of high porosity would allow rapid tissue in-growth and permit the functional maturation and alignment of tendon-like tissue, scaffolds were sutured to the superficial surface of the infraspinatus tendons of adult sheep. Histology demonstrated complete ingrowth with fibrovascular tissue by 6 weeks and by 12 weeks the scaffold had induced the forma...

introduction: brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. materials and methods: human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

Dear Friends, Nanofibrous scaffolds have been a major revolution in the field of tissue engineering which may improve the health and quality of life by enhancing tissue function. These are the artificial extracellular matrices which offer natural surroundings for tissue formation. Owing to their high surface to volume ratio, nanofibrous scaffolds increase cell adhesion, proliferation, and diffe...

Tissue engineering and regenerative medicine aim to produce tissue substitutes to restore lost functions of tissues and organs. This includes cell therapies, induction of tissue/organ regeneration by biologically active molecules, or transplantation of in vitro grown tissues. This review article discusses advanced cell therapies that make use of scaffolds and scaffold-free approaches. The first...