Objective(s): The present study aimed to prepare polycaprolactone (PCL) scaffolds with high porosity and pore interconnectivity, in order to copy the microstructure of natural bones using the thermally induced phase separation (TIPS) technique. Materials and Methods: The scaffolds were coated with chitosan (CH), bioactive glass (BG), and gelatin nanoparticles (GEL NPs) and assessed using ...

New three-dimensional (3D) scaffolds for bone tissue engineering have been developed throughout which bone cells grow, differentiate, and produce mineralized matrix. In this study, the percentage of cells anchoring to our polymer scaffolds as a function of initial cell seeding density was established; we then investigated bone tissue formation throughout our scaffolds as a function of initial c...

Biodegradable polymers have great number of applications in modern reconstructive medicine and orthopaedics. One of them is manufacturing of tissue engineering scaffolds, which are potential analogues of bone grafts. Bone scaffolds are commonly used to support reconstruction of tissue losses caused by injury or disease. The main goal of using the tissue engineered scaffolds is to maintain the m...

Development of engineered tissue scaffolds with superior control over cell-protein interactions is still very much infancy. Advancing through heterogeneous multifold scaffolds with controlled release fashion enables synchronization of regenerating tissue with the release kinetics of loaded biomolecules. This might be an engineering challenge and promising approach for improved and efficient tis...

Tissue engineering (TE) combines scaffolds, cells, and chemical physical cues to replace biological tissues [...]