نتایج جستجو برای: tnfaip3
تعداد نتایج: 403 فیلتر نتایج به سال:
A20 [also known as TNFAIP3 (tumour necrosis factor α-induced protein 3)] restricts and terminates inflammatory responses through modulation of the ubiquitination status of central components in NF-κB (nuclear factor κB), IRF3 (interferon regulatory factor 3) and apoptosis signalling cascades. The phenotype of mice with full or conditional A20 deletion illustrates that A20 expression is essentia...
BACKGROUND Genome-wide association studies (GWASs) of asthma have consistently implicated the ORM1-like 3 and gasdermin B (ORMDL3-GSDMB), IL33, IL-1 receptor-like 1 and IL-18 receptor 1 (IL1RL1-IL18R1), RAD50-IL13, thymic stromal lymphopoietin and WD repeat domain 36 region (TSLP-WDR36), and HLA-DR/DQ regions. OBJECTIVE A GWAS of asthma was performed in a non-Hispanic white population. METH...
search Institute, Cleveland, OH; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA; Department of Pediatrics, University of Virginia Health Systems, Charlottesville, VA; Brigham & Women’s Hospital, Harvard University, Boston, MA; Departments of Medicine and Public Health Sciences, University of Wisconsin Hospitals and Clinics, Madison, WI; Medicine, University of Pittsb...
OBJECTIVE Our previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To identify more coeliac disease loci, we selected 458 single nucleotide polymorphisms (SNPs) that showed more modest association in the GWAS for genotyping and analysis in four independent cohorts. DESIGN 458 SNPs were ...
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