BACKGROUND The efficacy of many preparations for topical use in herpes infections have remained rather disappointing. The development of new antiviral drugs, especially herbal preparations, thus remains desirable. In a screening study with plant extracts, a rhubarb root extract and a sage extract showed a promising activity. OBJECTIVE The efficacy of a combined topical preparation with rhubar...

The suf operon encoding a Fe-S assembly system is induced by peroxides through activators OxyR and IscR in Escherichia coli. For apo-IscR to bind, oxidation-mediated dissociation of Fur is required. Therefore, a peroxide-responsive signal is transduced through OxyR, IscR, and Fur to achieve oxidation-sensitive and maximal induction of this operon.

C O GI bleeding (GIB) remains a major cause of morbidity and mortality worldwide. Endoscopic management of GIB could be challenging, despite the existing advancements in hemostatic techniques; there are unmet needs for the introduction of topical hemostatic agents in management of profound venous or arterial GIB and malignant lesions with a large surface area that are not quite amenable to trad...

Objective: The aim of this study was to investigate the physicochemical and microbiological stability extemporaneous amitriptyline hydrochloride (AMH) topical preparations for treatment neuropathic pain. Materials Methods: AMH tablets were triturated produce fine powders with a mortar pestle. These levigated separately incorporated into four compounding bases: hydrophilic petrolatum USP, anioni...