Topical anesthetics are one of the first line therapeutical options for men with premature ejaculation (PE). Real-life PE management often involves a range interventions including systemic drug treatments (such as off-label and on-label selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, phosphodiesterase-5 (PDE5Is)), topical anesthetic creams sprays, behavioral approach...

There are no conflicts of interest. midazolam versus Sufentanil‑midazolam for awake fiberoptic nasotracheal intubation: A randomized double‑blind study. effective dose of remifentanil for awake laryngoscopy and intubation. airway topical anesthesia in patients with a difficult airway: A randomized, double‑blind comparison of 2% and 4% lidocaine. Comparison of dexmedetomidine and sufentanil for ...

BACKGROUND Vapocoolant sprays are commonly used to minimize pain following minor interventions such as venipuncture, shave biopsy or needle insertion. Although these sprays have been widely used in clinical practice, little is known about their effect on microcirculation or cutaneous blood flow. OBJECTIVE To evaluate the real-time effect of a topical vapocoolant using a well-established, rat ...

The aim of this study was to do determine the efficacy of the topical anaesthetic Tri-Solfen® in the amelioration of the pain of castration in piglets. The trial was conducted over a three day period, and blocked across six litters with 12 piglets treated on days one and two, and 16 on day three. The piglets were randomly allocated by weight and litter to 1 of 4 treatment groups: (i) sham castr...

BACKGROUND Chronic rhinosinusitis (CRS) is a common disease that can significantly impact health. The mainstay of medical treatment is topical steroids and oral antibiotics, but little is known about the efficacy of topical antibiotics. The purpose of this study was to identify evidence for the use of topical antibiotics in the treatment of CRS and exacerbations of CRS. METHODS Systematic rev...

OBJECTIVES This study aims to examine the effect of topical mometasone furoate nasal spray on nasal Staphylococcus aureus (S. aureus) colonization in the treatment of allergic rhinitis. PATIENTS AND METHODS Between January 2012 and February 2013, 53 patients having perennial allergic rhinitis symptoms (37 females, 16 males) and 53 healthy controls (36 females, 17 males) were included in the s...

The purpose of this study was to evaluate the effects of a topical spray containing 0.0584% hydrocortisone aceponate (HCA) on canine atopic dermatitis (CAD) and to evaluate the skin barrier function during the treatment of CAD. Twenty-one dogs that fulfilled the diagnostic criteria for CAD were included in this study. The HCA spray was applied once a day to the lesions of all dogs for 7 or 14 d...

The study aimed to ascertain the efficacy of oropharyngeal topical 10% lignocaine spray applied prior to induction of anaesthesia and also to determine the optimal time for spraying to attenuate pressor response to laryngoscopy and endotracheal intubation. 80 patients of either sex, in the age group of 20-60 years (ASA I & II) undergoing different elective surgical procedures under general anae...