The TOR (target of rapamycin) kinase is present in nearly all eukaryotic organisms and regulates a wealth of biological processes collectively contributing to cell growth. The genome of the model plant Arabidopsis contains a single TOR gene and two RAPTOR (regulatory associated protein of TOR)/KOG1 (Kontroller of growth 1) and GβL/LST8 (G-protein β-subunit-like/lethal with Sec thirteen 8) genes...

The TOR (target of rapamycin), an atypical protein kinase, is evolutionarily conserved from yeast to man. Pharmacological studies using rapamycin to inhibit TOR and yeast genetic studies have provided key insights on the function of TOR in growth regulation. One of the first bona fide cellular targets of TOR was the mammalian protein kinase p70 S6K (p70 S6 kinase), a member of a family of kinas...

Patterning of the Drosophila embryonic termini by the Torso (Tor) receptor pathway has long served as a valuable paradigm for understanding how receptor tyrosine kinase signaling is controlled. However, the mechanisms that underpin the control of Tor signaling remain to be fully understood. In particular, it is unclear how the Perforin-like protein Torso-like (Tsl) localizes Tor activity to the...

With Tor being a popular anonymity network, many attacks have been proposed to break its anonymity or leak information of a private communication on Tor. However, guaranteeing complete privacy in the face of an adversary on Tor is especially difficult because Tor relays are under complete control of world-wide volunteers. Currently, one can gain private information, such as circuit identifiers ...

Activation of the Drosophila receptor tyrosine kinase Torso (Tor) only at the termini of the embryo is achieved by the localized expression of the maternal gene Torso-like (Tsl). Tor has a second function in the prothoracic gland as the receptor for prothoracicotropic hormone (PTTH) that initiates metamorphosis. Consistent with the function of Tor in this tissue, Tsl also localizes to the proth...

issue of Aging further extends our understanding of the growing connection between the TOR pathway and mitochondrial function [1]. Interest in the TOR pathway for the aging community was initially spurred by a flurry of reports suggesting that in various model organisms, inhibition of this pathway could trigger lifespan extension [2-5]. In yeast, the TOR pathway regulates a number of diverse bi...

This new protocol is based on the idea of introducing a revocable anonymity in Tor, which was presented in our recent paper entitled "Another Tor is possible". Compared to that previous paper, this present scheme simplify the first protocol and reduce the power of the directory server, while maintaining the ability for the Tor community, to break the anonymity of a sender in case of misconduct....

Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily-conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although T...

In this paper we propose a new micropayments scheme which can be used to reward Tor relay operators. Tor clients do not pay Tor relays with electronic cash directly but submit proof of work shares which the relays can resubmit to a crypto-currency mining pool. Relays credit users who submit shares with tickets that can later be used to purchase improved service. Both shares and tickets when sen...

The target of rapamycin (TOR) is a conserved Ser/Thr kinase that regulates cell growth and metabolism in response to environmental cues. Here, highlighting contributions from studies in model organisms, we review mammalian TOR complexes and the signaling branches they mediate. TOR is part of two distinct multiprotein complexes, TOR complex 1 (TORC1), which is sensitive to rapamycin, and TORC2, ...