Essential oil of Juniperus oxycedrus growing in Algeria was obtained by steam distillation extraction method. The oil was analysed by capillary columns (non-polar DB5 and HP-chiral-20B) using gas chromatography with flame ionization and mass spectrometric detections. The compounds were identified according to their retention indices and mass spectra (EI, 70 eV). The oil contained α-pinene (36.7...

An overview of the development of anti-tumor organotin derivatives in selected classes of compounds is presented and discussed. High to very high in vitro activity has been found, sometimes equaling that of doxorubicin. Solubility in water is an important issue, dominating the in vivo testing of compounds with promising in vitro properties. The cytotoxicity of the compounds was increased by the...

A library of oligomeric compounds was synthesized based on the imidazole-4,5-dicarboxylic acid scaffold along with amino acid esters and chiral diamines derived from amino acids. The final compounds incorporate nonpolar amino acids (Leu, Phe, Trp), polar amino acids (Ser, Asp, Arg), and neutral amino acids (Gly, Ala), and were designed to be useful in screening for inhibitors of protein-protein...

physical and chemical properties of  crude oil, including viscosity and api gravity, are commonly inherited  from the  early organic matter, environmental conditions in which they were deposited and depth of burial of the source beds. api gravity increases in deeper burial due to higher thermal maturation of organic matter in the source rocks and consequently, generation of lighter saturated hy...

We were able to purify two distinct sodium pump inhibitors to homogeneity from human urine based on [3H]ouabain-displacing activity from intact human erythrocytes. The polar and less polar compounds were eluted off the C18 reverse-phase column with 18% and 31% acetonitrile, respectively. The polar compound cross-reacted very weakly with specific antidigoxin antibody and lacked a characteristic ...

Pyrene-based compounds have a great potential as fluorescent chemosensors for various analytes including common nitro-explosives, such 2,4,6-trinitrotoluene (TNT). Compounds having two pyrene units in one molecule, bispyrenylalkanes, are able to form stable, bright emissive visual wavelength region excimers both non-polar and polar environments. In this work we wish report that solvents the exc...

Purpose: Poly (3-hydroxybutyrate-hydroxyvalerate) displayed high dipole-dipole interaction, a high hydrogen bonding but low polar interaction, and was therefore expected to be miscible with solvents/plasticizers that exhibit similar pattern of cohesive interaction. To determine the applicability, or otherwise of the theory of the three dimensional solubility parameters to the formulation of pol...

In recent years, there has been growing interest in the potential medicinal benefits of Syzygium cumini. This is due part to plant's rich content antioxidants, flavonoids, and other phytochemicals. These compounds have shown a variety beneficial effects, including antidiabetic, anti-inflammatory, anti-cancer properties. The solvent plays an important role extraction from study aimed conduct sys...

Oral bioavailability measurements in rats for over 1100 drug candidates studied at SmithKline Beecham Pharmaceuticals (now GlaxoSmithKline) have allowed us to analyze the relative importance of molecular properties considered to influence that drug property. Reduced molecular flexibility, as measured by the number of rotatable bonds, and low polar surface area or total hydrogen bond count (sum ...

Deproteinisation with acetonitrile (along with methanol or other reagents) is a useful and rapid technique in analysis of drugs or their metabolites in human serum. In this paper application of this simple technique in biopharmaceutical analysis using capillary electrophoresis (CE) is evaluated. Some drugs with different ionic and protein binding properties were selected and dissolved in human ...