Examples of toxic cardiomyopathies of various characteristics are presented. Daunomycin and doxorubicin, antineoplastic drugs, cause multifocal cardiomyopathies and intractable heart failure by cardiotoxic mechanisms; these effects are delayed and related to the cumulative dose. Cobalt caused diffuse vacuolar cardiomyopathy in chronic beer drinkers. The development of fulminant heart failure wa...

4-Hydroxyanisole (4-OHA) was administered to C57Bl/lOJ mice in which B16 melanoma or Lewis lung carcinoma had been implanted s.c. or i.m. The drug had the largest antitumour effect against B16 melanoma growing s.c. and a smaller antitumour effect against B16 melanoma or Lewis lung carcinoma growing i.m. In the treatment regimens where drug was administered only after tumour implantation, a sign...

history of excessive perspiration three months previously, followed two weeks later by a "sweat rash." She became very fretful, refused her food, and did not sleep. There was marked photophobia. She was admitted to hospital, and kept on sedatives to procure sleep. She took her feeds better, but began to have a temperature; loose motions followed, and eventually she died of gastro-enteritis. In ...

Introduction. Non-ferrous smelters are one of the critical nanoscale cadmium particles sources in workplace and ambient air. Materials methods. The research was performed to evaluate subchronic toxicity oxide nanoparticles (CdO-NPs) white outbred rats. Male 3.5-month old rats received intraperitoneal injections CdO-NPs 3 times a week for six weeks (18 total) doses 0.25 mg/kg body mass. After en...

PURPOSE This article reviews the most important muscle toxins, many of which are widely prescribed medications. Particular emphasis is placed on statins, which cause muscle symptoms in a relatively large proportion of the patients who take them. RECENT FINDINGS As with other toxic myopathies, most cases of statin-associated myotoxicity are self-limited and subside with discontinuation of the ...

By ARIF I. CETINGIL AND MUHLIS A. OZEN T HE EXCESSIVE porphyrin excretion seen in idiopathic disturbances of porphyrin metabolism must be differentiated from the porphyrinuria that occurs in various diseases associated with alterations in porphyrin metabolism. Porphyrinuria can he observed in the course of various diseases and may result from the intake of various drugs and poisons. It is well ...

In This Issue In This Issue Toxic apoptosis antel et al. report that ␣-toxin from Staphylococcus aureus can induce apoptosis in immune cells (page 637). This may help the bacterium to immunosuppress the victim and continue proliferating. S. aureus was known to induce apoptosis, but the underlying mechanism was unknown. Bantel et al. find that the inducer is soluble. B Apoptosis can be triggered...