chlorpyrifos is one of the organophosphate pesticides that are commonly used to control insects in domestic activities and many agricultural farms that are located in close to water sources. hence, the present study, investigate the lethal toxicity of this pesticide. in this study, fish were treated in groups of 21 with different concentrations of chlorpyrifos (aria brand with active ingredient...

PURPOSE The toxicity of antiglaucoma medications to ocular surface cells has been evaluated extensively; however, the toxicity to corneal endothelial cells (CECs) remains elusive. Our aim is to evaluate the toxicity of antiglaucoma medications to CECs using an in vitro toxicity assay. METHODS Primary cultures of human (H) CECs derived from eye bank specimens were established. Following exposu...

Pyrethroid insecticides are known for their potential toxicity to aquatic invertebrates and many fish species. A significant problem in the study of pyrethroid toxicity is their extreme hydrophobicity. They can adsorb to test container surfaces and many studies, therefore, report pyrethroid levels as nominal water concentrations. In this study, pyrethroid adsorption to sampling and test contain...

This work investigates the ecotoxicological evaluation of contaminated dredged sediments from French Mediterranean navy harbour (A), commercial port (B) and two composite specimens (C) and (D) coming from the mixture of A and B with other port sediments. The toxicity of elutriates from these sediments is estimated using embryo-toxicity test, Microtox® solid phase test, LuminoTox, phytotoxicity ...

Artemia is one of the most important test organisms available for ecotoxicity test. In this study the toxicity of five widely used herbicides formulations including: Paraquat, 2,4-dichlorophenoxy acetic acid (2,4-D), Trifluralin, Glyphosite and Atrazin were compared using ecotoxicity bioindicator, Artemia franciscana. Acute toxicity (48 h LC50) of five herbicides were determined via OECD standa...

BACKGROUND Risk assessment of chemicals and other agents must be accurate to protect health. We analyse the determinants of a sensitive chronic toxicity study, risk assessment's most important test. Manufacturers originally generate data on the properties of a molecule, and if government approval is needed to market it, laws globally require toxicity data to be generated using Test Guidelines (...

PURPOSE To evaluate the pharmacokinetics of weekly docetaxel in a cohort of older patients with metastatic cancer and to explore the relationship of pharmacokinetic variables, Erythromycin Breath Test results, age, geriatric assessment variables, and toxicity to therapy. EXPERIMENTAL DESIGN Twenty patients ages > or = 65 years with metastatic breast, prostate, or lung cancer entered an Instit...

Nonionic surfactants are amphilic chemicals that enhance desorption and bioavailability by increasing solubility and dispersion of poorly soluble hydrocarbons and oils. This study was conducted to determine the toxicity of commercial nonionic surfactants by using the Microtox Acute Toxicity test which is a rapid, simple test for toxicity. The test uses the luminescent bacterium V. fischeri as t...

The toxicity of many metals is impacted by environmental pH, through both competition and complexation by hydroxide and carbonate ions. To establish safe environmental regulation it is important to properly define the relationship between pH and metal toxicity, a process that involves manipulating the pH of test water in the lab. The current study compares the effects of the three most common p...