The medullary vagal motor nuclei, the nucleus ambiguus (NA) and dorsal motor nucleus of the vagus (DMV), innervate the respiratory and gastrointestinal tracts. We conducted immunohistochemical analysis of expression of the androgen receptor (AR) and estrogen receptor α (ERα), in relation to innervation of the trachea and esophagus via vagal motor nuclei in mice. AR and ERα were expressed in the...

The mammalian respiratory system, consisting of both trachea and lung, initiates from the foregut endoderm. The molecular program that instructs endodermal cells to adopt the respiratory fate is not fully understood. Here we show that conditional inactivation of beta-Catenin (also termed Ctnnb1) in foregut endoderm leads to absence of both the trachea and lung due to a failure in maintaining th...

FIZZ1 is an adipokine highly expressed under inflammatory conditions, and yet, little is known of its function. In this study we examine the expression and function of FIZZ1 in an ovalbumin mouse model of asthma. Trachea from naïve or ovalbumin-sensitised and -challenged mice were compared for transcriptional, functional and proteomic differences using gene microarrays, ex vivo tracheal contrac...

The Larynx, trachea and the main bronchi together form the extrapulmonary lower airways. After air has been warmed and moistened in the upper airways (nose and pharynx), it passes through the larynx – the guardian of the airways. the larynx separates the trachea from the esophagus and is the organ from which voice is produced. The air then passes the tube-shaped trachea, which bifurcates into t...

A 44-year-old male presented with progressing cough, dyspnea and hemoptysis due to a tracheal tumor involving the posterior wall of the lower trachea, with severe airway obstruction and coagulopathy. Consequently the patient underwent segmental resection of the trachea with an end-to-end anastomosis. Twenty months after treatment there remained no evidence of endobronchial recurrence at broncho...

Yazdanbakhsh et al. [1] report a surgical technique using autologous pericardial patch and strips of costal cartilage for relieving severe tracheal stenosis. Over nearly two decades of experience, 21 patients were treated, with 3 (14%) suffering late postoperative mortality. Seven patients underwent bronchoscopic reintervention and 8 underwent surgical intervention, including 3 sliding tracheop...

introduction: the distance between the anterior commissure of the larynx and the first tracheal ring (ac.t. distance) is of great importance in laryngotracheal surgeries.  the amount of narrowing of the subglottic airway is used as a quantitative mean to determine whether the lesion is subglottic or has extended to the trachea and therefore helps in the prediction of the final prognosis.   mate...

Surgical strategy for patients with papillary thyroid carcinoma invading the trachea: a comparison of tracheal sleeve resection end-to-end anastomosis and window tracheocutaneous fistula

Accessory bronchi arising from the trachea 'are rare in man (Boyden, 1955) but common in lower animals (McEwen, 1937). When present they commonly arise from the right side of the trachea, approximately 2 cm. above the origin of the right main bronchus (Brock, 1954). Accessory bronchi may be displaced normal branches or true supernumerary bronchi (FosterCarter, 1946). In the former the accessory...