BACKGROUND Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) has been reported to be associated with the development of various cancers. However, the role of TRAF6 in lung cancer remains unclear. OBJECTIVE To explore the expression and clinicopathological significance of TRAF6 protein in lung cancer tissues. MATERIALS AND METHODS Three hundred and sixty-five lung cancer sampl...

عاطقلا طبر ي يذ لا ة يبرهكلا ىو قلا ماظنل يكيمانيدلارارقتسلال ةضيفتسم ةيلمع ةسارد ثحبلا اذه مدقي ني ب ة لوقنملا ةرد قلا ةدا يز ى لع ك لذ ريثأ ت و ةيدوعس لا ءا برهآ ةآر ش ن م ط سولأا عا طقلا و يقرش لا نيعاطقلا ، ىوقلا مظن تاتبثم طبض للاخ نم كلذو . دقل شم ةغايص مت ةلك طبض ةروص ىف تاتبثملا هذه ةلثمأ ةلكشم . ماظنلا ءادأ نيسحتل ك لذو ةدر فنملا ماظنلا ميق ىلع نادمتعت فده يتلاد حارتقا مت دقلو . د قلو ...

يفكي هنأ نيبن ،ثحبلا اذه يف ةيقفأ حئارش تاطاقسإ هيمسن ام لثم باسحلا ةلهس ملاعم مادختسا ايلآ ةعوبطملا فورحلا ىلع يئوضلا فرعتلا ةلأسم ةءافكب لحت يكل ةيسأرو . ةرجش مادختساب فرعتلا متي حاجنلا لدعم ةدايزل ىرخأ تافاضإ عم ةدمعأو فوفص فذحو ميعنتو عوجر تايلآب ةموعدم رارق . و مدختسن ماظنلا بيردتل طخ نم زومر Times New Roman . دق فذحلاو ميعنتلاو عوجرلا ليعفت نإ لاًدعم ققح حجان اً زواجت 98 % نم لقأ فرعت نمزب ...

TRANCE/TRAF6 signalling governs osteoclastogenesis in vivo. Only the TRANCE receptor (TRANCE-R) has been shown to induce osteoclastogenesis, even though other immune receptors, including CD40 and IL-1R/Toll-like receptor, use TRAF6 to activate overlapping signalling cascades. These observations led us to question whether qualitative or quantitative differences exist between the TRAF6-mediated s...

Chronic low-grade inflammation, adipocyte hypertrophy, and glucose intolerance are common features of obesity and a risk factor for cancer. Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is an adaptor protein that also possesses a non-conventional E3 ubiquitin ligase activity. In response to receptor-mediated events, TRAF6 activates transforming growth factor-activated kinase ...

In recent years, interests combining the exploration of tumor necrosis factor receptor-associated factor 4 (TRAF4) and TRAF6 in immune cells and transgenic mice are emerging. Although it has been found that TRAF4 and TRAF6 share the same TRAF binding sites, comprehensive study of TRAF4 and TRAF6 in inflammatory bowel disease (IBD) is still lacking. This paper shows similar and different express...

Recognizing TimeML events and identifying their attributes, are important tasks in natural language processing (NLP). Several NLP applications like question answering, information retrieval, summarization, and temporal information extraction need to have some knowledge about events of the input documents. Existing methods developed for this task are restricted to limited number of languages, an...

IL-1 receptor (IL-1R)/Toll-like receptor (TLR) family and TNF receptor (TNFR) superfamily members are critical for regulating multiple aspects of dendritic cell (DC) biology. Several signaling pathways associated with each family utilize the adapter molecule, TRAF6, but its role in DCs is unclear. By examining TRAF6-deficient mice and bone marrow (BM) chimeras reconstituted with TRAF6-deficient...

BACKGROUND Tumor necrosis factor receptor-associated factors (TRAFs) are important signaling molecules for a variety of pro-atherogenic cytokines including CD40L, TNF alpha, and IL1beta. Several lines of evidence identified TRAF6 as a pro-inflammatory signaling molecule in vitro and we previously demonstrated overexpression of TRAF6 in human and Murine atherosclerotic plaques. This study invest...

In this study, Four Wave Mixing (FWM) characteristics in photonic crystal fibers are investigated. The effect of channel spacing, phase mismatching, and fiber length on FWM efficiency have been studied. The variation of idler frequency which obtained by this technique with pumping and signal wavelengths has been discussed. The effect of fiber dispersion has been taken into account; we obtain th...