Background and objective: Local anesthetics and morphine have been reported to be useful for painful diagnostic procedures in the bladder. Tramadol has the potential for use as an intravesical analgesic. However, intravesical use of tramadol has not been described widely. Methods: This study was approved by the Animal Ethical Committee of Akdeniz University and performed with standard guideline...

AIM Nerve entrapment syndromes are the most common causes of neuropathic pain. Surgical decompression is the preferred method of treatment. The aim of this study was to compare the efficacy of curcumin, tramadol and chronic constriction release treatment (CCR), individually or together, in a rat model of sciatic nerve injury. MATERIAL AND METHODS Eighty male rats were divided into eight study...

background: prevalence of recurrent shoulder dislocation in patients taking tramadol has not been studiedyet so, this study aims to study the recurrent shoulder dislocation following tramadol induced seizure. methods: in this cross-sectional study, 205 patients with recurrent shoulder dislocation complaints (2 or more) referred to shafa orthopedic and iranmehr hospitals tehran, iran, from octob...

PURPOSE Optimal analgesia in ambulatory urology patients still remains a challenge. The aim of this study was to examine if the pre-emptive use of intravenous tramadol can reduce pain after ureteroscopic lithotripsy in patients diagnosed with unilateral ureteral stones. MATERIALS AND METHODS This prospective pilot cohort study included 74 patients diagnosed with unilateral ureteral stones who...

BACKGROUND The aim of present study was to investigate the antinociceptive effect of pregabalin and tramadol either alone and or in combination on acute model of pain. METHODS The antinociceptive effect of intraperitoneal administration of pregabalin (1 to 400 mg/kg) and tramadol (10 to 80 mg/kg) or combination of them were measured after 30 and 60 min on hot-plate in terms of maximum possibl...

UNLABELLED There has been growing interest in determining the possible immune consequences of opioid administration for the management of postoperative pain. We studied the effects of morphine and tramadol on pain and immune function during the postoperative period in 30 patients undergoing abdominal surgery for uterine carcinoma. Phytohemoagglutinin-induced T lymphocyte proliferation and natur...

Morphine and tramadol which have analgesic effects can be administered acutely or chronically. This study tried to investigate the effect of these drugs at various times by using different methods of administration (intraperitoneal, oral, acute and chronic). Sixty adult female rats were divided into six groups. They received saline, morphine or tramadol (20 to 125 mg/Kg) daily for 15 days. A ho...

Abstract: Tramadol is most commonly used opioid analgesic. It has a very rare and serious endocrine metabolic side effect as hypoglycaemia. The reason behind hypoglycaemia still unclear but it may lead due to increased insulin concentration utilization of glucose by muscles. In this report, patient prescribed tramadol for toothache. This report focuses on administration. Clinical Pharmacists sh...

BACKGROUND It has been almost three decades since tramadol was introduced to the market as a centrally acting analgesic. It is claimed to have weak opioid properties and a low dependence potential in opioid-addicted patients. This study was designed to investigate the suspicion of potential tramadol abuse among patients visiting pharmacies in Babol, one of the major cities in northern Iran. M...

IMPORTANCE Tramadol is a weak opioid analgesic whose use has increased rapidly, and it has been associated with adverse events of hypoglycemia. OBJECTIVE To assess whether tramadol use, when compared with codeine use, is associated with an increased risk of hospitalization for hypoglycemia. DESIGN, SETTING, AND PARTICIPANTS A nested case-control analysis was conducted within the United King...