The aerial parts of Tephrosia carrollii afforded two chromene chalcones. Their structures and stereochemistry were established by spectroscopic methods. The structure of oaxacacin was revised and confirmed by X-ray diffraction. In this paper, we describe the isolation of the chalcone known as "oaxacacin" and the new chalcone named epoxyobovatachalcone. The compound der. oaxacacin was found to b...

The α-methylated chalcone 3 with an electron-donor substituted A-aryl ring and unsubstituted B-phenyl was synthesized by base-catalyzed aldehyde/acetophenone condensation. Compound can be photo-switched from E→Z irradiation long-wavelength light λ > 350 nm, whereas shorter wavelengths leads to photo-stationary states (PSS) lower amounts of the Z-isomer. limiting wavelength for fully equilibr...

Using a routine procedure, a number of derivatives of the benzo[4,5]isothiazolo[2,3-a]pyrazine-6,6-dioxide ring system have been synthesized from readily available starting materials. A series of chalcones were synthesized, which were subsequently reacted with chlorosulfonic acid to generate chalcone sulfonyl chlorides. The chalcone sulfonyl chlorides were then treated with bromine to generate ...

The methanol and fractionated extracts (hexane, ethyl acetate and water) of Alpinia mutica (Zingiberaceae) rhizomes were investigated for their cytotoxic effect against six human carcinoma cell lines, namely KB, MCF7, A549, Caski, HCT116, HT29 and non-human fibroblast cell line (MRC 5) using an in vitro cytotoxicity assay. The ethyl acetate extract possessed high inhibitory effect against KB, M...

Quorum Sensing is a special system between bacteria to communicate with the signal molecules. Propolis resin collected from plants by honey bees. The present study examined anti-quorum sensing and antimicrobial activities of water ethanol extracts propolis. propolis were studied against Escherichia coli ATCC 25922 Gram (-), Listeria monocytogenes 7644, Streptococcus mutans CNCTC 8/77, Staphyloc...

Two new prenylchalcones, xanthohumol C and D, together with two known prenylchalcone derivatives, xanthohumol (1) and 5''-(2''-hydroxyisopropyl)-dihydrofurano-[2'',3''-b]-4,4'-dihydroxy-6'-methoxy-chalcone (4) were isolated and identified from the hops of Humulus lupulus L. The structures of xanhohumol C and D were elucidated as 5''-hydroxy-6'',6''-dimethyl-dihydropyrano-[2'',3''-b]-4,4'-dihydr...

3518 Cell Cycle Volume 11 issue 18 Olga A. Issaenko and Alexander Yu Amerik, authors of the recently published paper, “Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes” wish to make the following clarifications regarding compound names referenced therein. 1. The authors note that on pages 1809 and 1810, the label and the legend for Fi...

The Effect of Chalcone Isomerase (Chi) Gene Silencing on Flavonoids Content in Petunia hybrida using RNAi Technology

Several years of extensive research using the new powerful techniques of molecular biology have enabled the direct comparison of functionally or evolutionarily related genes and their products at the nucleotide and amino acid sequence levels. Two types of synthase with similar functions are discussed as an interesting example. Stilbene synthases, e.g. resveratrol synthase, produce the stilbene ...

Flavonoids and isoflavonoids are major plant secondary metabolites that mediate diverse biological functions and exert significant ecological impacts. These compounds play important roles in many essential physiological processes. In addition, flavonoids and isoflavonoids have direct but complex effects on human health, ranging from reducing cholesterol levels and preventing certain cancers to ...